Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16725
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dc.contributor.authorWeinberg, Laurence-
dc.contributor.authorJang, Jae-
dc.contributor.authorRachbuch, Clive-
dc.contributor.authorTan, Chong O-
dc.contributor.authorHu, Raymond-
dc.contributor.authorMcNicol, Larry-
dc.date.accessioned2017-07-26T00:50:05Z-
dc.date.available2017-07-26T00:50:05Z-
dc.date.issued2017-07-06-
dc.identifier.citationBMC Research Notes 2017; 10: 248en_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16725-
dc.description.abstractBACKGROUND: Lignocaine is a local anaesthetic agent, which is also commonly used as a perioperative analgesic adjunct to accelerate rehabilitation and enhance recovery after surgery. Lignocaine's systemic effects on intraoperative haemodynamics and volatile anaesthetic requirements are not well explored. Therefore, we evaluated the effects of intravenous lignocaine on intraoperative volatile agent requirements and haemodynamics in patients undergoing major abdominal surgery. METHODS: We performed an analysis of 76 participants who underwent elective open radical retropubic prostatectomy. Patients received lignocaine (1.5 mg/kg loading dose) followed by an infusion (1.5 mg/kg/h) for the duration of surgery, or saline at an equivalent rate. The aims of the study were to evaluate the end-tidal sevoflurane concentration required to maintain a bispectral index of between 40 and 60. Measurements included intraoperative blood pressure, heart rate, and the volume of intravenous fluids and dosage of vasoactive medications administered. RESULTS: The average end-tidal sevoflurane concentration was lower in the Lignocaine group compared to saline [1.49% (SD: 0.32) vs. 1.89% (SD: 0.29); 95% CI 0.26-0.5, p < 0.001]. In the Lignocaine group, the average mean arterial pressure was 80.3 mmHg (SD: 4.9) compared to 85.1 mmHg (SD: 5.4) in the Saline group (95% CI 2.4-7.1, p < 0.001). Systolic blood pressure was also lower in the Lignocaine group: 121.7 mmHg (SD: 6.1) vs. 128.0 mmHg (SD: 6.4) in the Saline group; 95% CI 3.5-9.2, p < 0.001, as was the mean heart rate [Lignocaine group: 74.9 beats/min (SD: 1.8) vs. 81.5 beats/min (SD: 1.7) in the Saline group, 95% CI 4.1-9.1, p < 0.001]. Maintenance fluid requirements were higher in the Lignocaine group: 3281.1 mL (SD: 1094.6) vs. 2552.6 mL (SD: 1173.5) in the Saline group, 95% CI 206-1251, p = 0.007. There were no differences in the use of vasoactive drugs. CONCLUSIONS: Intravenous lignocaine reduces volatile anaesthetic requirements and lowers blood pressure and heart rate in patients undergoing open radical prostatectomy.en_US
dc.subjectBlood pressureen_US
dc.subjectDepth of anaesthesiaen_US
dc.subjectFluidsen_US
dc.subjectHaemodynamicsen_US
dc.subjectLidocaineen_US
dc.subjectLignocaineen_US
dc.subjectSevofluraneen_US
dc.subjectVolatile agentsen_US
dc.titleThe effects of intravenous lignocaine on depth of anaesthesia and intraoperative haemodynamics during open radical prostatectomyen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBMC Research Notesen_US
dc.identifier.affiliationFaculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australiaen
dc.identifier.affiliationDepartment of Surgery, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia, Eastern Health, Box Hill, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28683817en_US
dc.identifier.doi10.1186/s13104-017-2570-4en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-7403-7680en_US
dc.type.austinJournal Articleen_US
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
crisitem.author.deptAnaesthesia-
crisitem.author.deptAnaesthesia-
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