Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16687
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLim, Yen Ying-
dc.contributor.authorWilliamson, Robert-
dc.contributor.authorLaws, Simon M-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorBourgeat, Pierrick-
dc.contributor.authorFowler, Christopher-
dc.contributor.authorRainey-Smith, Stephanie R-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorMaruff, Paul-
dc.date2017-05-25-
dc.date.accessioned2017-06-25T23:58:35Z-
dc.date.available2017-06-25T23:58:35Z-
dc.date.issued2017-
dc.identifier.citationJournal of Alzheimer's Disease 2017; 58(4): 1293-1302en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16687-
dc.description.abstractBackground: The association between the apolipoprotein E (APOE) ɛ4 allele and high risk of developing Alzheimer’s disease (AD) dementia before the age of 80 has been recognized for over 30 years. However, the timing and mode of action of APOE is not understood, nor has there been a detailed analysis of the effect of APOE genotype on memory, hippocampal volume, and amyloid-β (Aβ) levels in cognitively normal adults. Objective: Examine the effect of APOE allelic genotype on the relationship between Aβ levels, hippocampal volume, and memory in cognitively normal adults. Methods: This is a cross-sectional study of 989 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, all of whom underwent APOE genotyping and memory assessment. A subset of this group underwent PET neuroimaging for Aβ (n = 585) and MRI for hippocampal volume (n = 303). Results: APOE ɛ4 homozygotes (ɛ4/ɛ4) showed significantly worse episodic memory and higher Aβ levels than ɛ4 heterozygotes. The relationship between increasing Aβ levels and worse episodic memory was significant for ɛ3 homozygotes (ɛ3/ɛ3), ɛ4 heterozygotes, and strongest for ɛ4 homozygotes. There were no differences in hippocampal volume between APOE groups; the relationship between smaller hippocampal volume and worse episodic memory was significant only for ɛ4 homozygotes. Conclusion: APOE acts in a co-dominant fashion on Aβ levels, episodic memory, and hippocampal volume in cognitively normal older adults. APOE ɛ4 is central to the events that lead to AD in cognitively normal older adults, likely through a quantitative role in the disruption of Aβ clearance.en
dc.subjectAlzheimer’s diseaseen
dc.subjectAmyloiden
dc.subjectApolipoprotein Een
dc.subjectHippocampal volumeen
dc.subjectMemoryen
dc.subjectMild cognitive impairmenten
dc.titleEffect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individualsen
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Alzheimer's Diseaseen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationCentre of Excellence for Alzheimer’s Disease Research and Care, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationCo-operative Research Centre for Mental Healthen
dc.identifier.affiliationSchool of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australiaen
dc.identifier.affiliationCSIRO Preventative Health National Research Flagship, Australian e-Health Research Centre-BiaMedIA, Brisbane, Queensland, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationCogstate Ltd., Melbourne, Victoria, Australiaen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28550258en
dc.identifier.doi10.3233/JAD-170072en
dc.type.contentTexten
dc.identifier.orcid0000-0003-3910-2453en
dc.type.austinJournal Articleen_US
local.name.researcherMasters, Colin L
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

38
checked on Dec 24, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.