Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16668
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dc.contributor.authorTraenka, Christopher-
dc.contributor.authorDougoud, Daphne-
dc.contributor.authorSimonetti, Barbara Goeggel-
dc.contributor.authorMetso, Tiina M-
dc.contributor.authorDebette, Stephanie-
dc.contributor.authorPezzini, Alessandro-
dc.contributor.authorKloss, Manja-
dc.contributor.authorGrond-Ginsbach, Caspar-
dc.contributor.authorMajersik, Jennifer J-
dc.contributor.authorWorrall, Bradford B-
dc.contributor.authorLeys, Didier-
dc.contributor.authorBaumgartner, Ralf-
dc.contributor.authorCaso, Valeria-
dc.contributor.authorBejot, Yannick-
dc.contributor.authorCompter, Annette-
dc.contributor.authorReiner, Peggy-
dc.contributor.authorThijs, Vincent-
dc.contributor.authorSoutherland, Andrew M-
dc.contributor.authorBersano, Anna-
dc.contributor.authorBrandt, Tobias-
dc.contributor.authorGensicke, Henrik-
dc.contributor.authorTouze, Emmanuel-
dc.contributor.authorMartin, Juan J-
dc.contributor.authorChabriat, Hugues-
dc.contributor.authorTatlisumak, Turgut-
dc.contributor.authorLyrer, Philippe-
dc.contributor.authorArnold, Marcel-
dc.contributor.authorEngelter, Stefan T-
dc.contributor.authorCADISP-Plus Study Group-
dc.date2017-04-04-
dc.date.accessioned2017-06-01T05:58:12Z-
dc.date.available2017-06-01T05:58:12Z-
dc.date.issued2017-04-04-
dc.identifier.citationNeurology 2017; 88(14): 1313-1320en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16668-
dc.description.abstractOBJECTIVE: In a cohort of patients diagnosed with cervical artery dissection (CeAD), to determine the proportion of patients aged ≥60 years and compare the frequency of characteristics (presenting symptoms, risk factors, and outcome) in patients aged <60 vs ≥60 years. METHODS: We combined data from 3 large cohorts of consecutive patients diagnosed with CeAD (i.e., Cervical Artery Dissection and Ischemic Stroke Patients-Plus consortium). We dichotomized cases into 2 groups, age ≥60 and <60 years, and compared clinical characteristics, risk factors, vascular features, and 3-month outcome between the groups. First, we performed a combined analysis of pooled individual patient data. Secondary analyses were done within each cohort and across cohorts. Crude and adjusted odds ratios (OR [95% confidence interval]) were calculated. RESULTS: Among 2,391 patients diagnosed with CeAD, we identified 177 patients (7.4%) aged ≥60 years. In this age group, cervical pain (ORadjusted 0.47 [0.33-0.66]), headache (ORadjusted 0.58 [0.42-0.79]), mechanical trigger events (ORadjusted 0.53 [0.36-0.77]), and migraine (ORadjusted 0.58 [0.39-0.85]) were less frequent than in younger patients. In turn, hypercholesterolemia (ORadjusted 1.52 [1.1-2.10]) and hypertension (ORadjusted 3.08 [2.25-4.22]) were more frequent in older patients. Key differences between age groups were confirmed in secondary analyses. In multivariable, adjusted analyses, favorable outcome (i.e., modified Rankin Scale score 0-2) was less frequent in the older age group (ORadjusted 0.45 [0.25, 0.83]). CONCLUSION: In our study population of patients diagnosed with CeAD, 1 in 14 was aged ≥60 years. In these patients, pain and mechanical triggers might be missing, rendering the diagnosis more challenging and increasing the risk of missed CeAD diagnosis in older patients.en_US
dc.subjectNeck Painen_US
dc.subjectVertebral Artery Dissectionen_US
dc.titleCervical artery dissection in patients ≥60 years: often painless, few mechanical triggersen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNeurologyen_US
dc.identifier.affiliationDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Switzerlanden_US
dc.identifier.affiliationDepartment of Neurology, University Hospital Berne, Berne, Switzerlanden_US
dc.identifier.affiliationOspedale San Giovanni, Bellinzona, Switzerlanden_US
dc.identifier.affiliationDepartment of Neurology, Helsinki University Central Hospital, Finlanden_US
dc.identifier.affiliationDepartment of Neurology, Bordeaux University Hospital, Bordeaux, Franceen_US
dc.identifier.affiliationInserm U1219, Bordeauxen_US
dc.identifier.affiliationBordeaux University, Bordeaux, Franceen_US
dc.identifier.affiliationDepartment of Neurology, Boston University School of Medicine, Boston, MA, USAen_US
dc.identifier.affiliationDepartment of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italyen_US
dc.identifier.affiliationDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germanyen_US
dc.identifier.affiliationDepartment of Neurology, University of Utah, Salt Lake City, UT, USAen_US
dc.identifier.affiliationDepartments of Neurology and Public Health Sciences, University of Virginia Health System, Charlottesville, VA, USAen_US
dc.identifier.affiliationUniv Lille 2, INSERM U 1171, CHU Lille, Franceen_US
dc.identifier.affiliationNeuro Center, Clinic Hirslanden, Zurich, Switzerlanden_US
dc.identifier.affiliationStroke Unit and Division of Internal and Cardiovascular Medicine, University of Perugia, Italyen_US
dc.identifier.affiliationCentre Hospitalier Universitaire Le Bocage, Dijon, Franceen_US
dc.identifier.affiliationDepartment of Neurology and Neurosurgery, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlandsen_US
dc.identifier.affiliationDepartment of Neurology, Lariboisière Hospital, Paris 7 University, DHU Neurovasc Sorbonne Paris Cité, Franceen_US
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationCerebrovascular Unit, IRCCS Foundation C. Besta Neurological Institute, Milan, Italyen_US
dc.identifier.affiliationClinics for Neurologic Rehabilitation, Kliniken Schmieder, Heidelberg, Germanyen_US
dc.identifier.affiliationNormandie Univ, UNICAEN, Inserm U919, Department of Neurology, CHU Caen, Franceen_US
dc.identifier.affiliationDepartment of Neurology, CH Sainte-Anne, University Paris Descartes, Franceen_US
dc.identifier.affiliationDepartment of Neurology, Sanatorio Allende, Cordoba, Argentinaen_US
dc.identifier.affiliationDepartment of Neurology, Sahlgrenska University Hospital and Institute for Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Swedenen_US
dc.identifier.affiliationNeurorehabilitation Unit, University of Basel and University Center for Medicine of Aging and Rehabilitation, Felix Platter Hospital, Basel, Switzerlanden_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28258079en_US
dc.identifier.doi10.1212/WNL.0000000000003788en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone-
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