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dc.contributor.authorO'Donnell, David-
dc.contributor.authorSperzel, Johannes-
dc.contributor.authorThibault, Bernard-
dc.contributor.authorRinaldi, Christopher A-
dc.contributor.authorPappone, Carlo-
dc.contributor.authorGutleben, Klaus-Jürgen-
dc.contributor.authorLeclercq, Christopher-
dc.contributor.authorRazavi, Hedi-
dc.contributor.authorRyu, Kyungmoo-
dc.contributor.authorMcspadden, Luke C-
dc.contributor.authorFischer, Avi-
dc.contributor.authorTomassoni, Gery-
dc.identifier.citationEuropace 2017; 19(4): 588-595en_US
dc.description.abstractAIMS: The aim of this study was to evaluate any benefits to the number of viable pacing vectors and maximal spatial coverage with quadripolar left ventricular (LV) leads when compared with tripolar and bipolar equivalents in patients receiving cardiac resynchronization therapy (CRT). METHODS AND RESULTS: A meta-analysis of five previously published clinical trials involving the Quartet™ LV lead (St Jude Medical, St Paul, MN, USA) was performed to evaluate the number of viable pacing vectors defined as capture thresholds ≤2.5 V and no phrenic nerve stimulation and maximal spatial coverage of viable vectors in CRT patients at pre-discharge (n = 370) and first follow-up (n = 355). Bipolar and tripolar lead configurations were modelled by systematic elimination of two and one electrode(s), respectively, from the Quartet lead. The Quartet lead with its four pacing electrodes exhibited the greatest number of pacing vectors per patient when compared with the best bipolar and the best tripolar modelled equivalents. Similarly, the Quartet lead provided the highest spatial coverage in terms of the distance between two furthest viable pacing cathodes when compared with the best bipolar and the best tripolar configurations (P < 0.05). Among the three modelled bipolar configurations, the lead configuration with the two most distal electrodes resulted in the highest number of viable pacing vectors. Among the four modelled tripolar configurations, elimination of the second proximal electrode (M3) resulted in the highest number of viable pacing options per patient. There were no significant differences observed between pre-discharge and first follow-up analyses. CONCLUSION: The Quartet lead with its four electrodes and the capability to pace from four anatomical locations provided the highest number of viable pacing vectors at pre-discharge and first follow-up visits, providing more flexibility in device programming and enabling continuation of CRT in more patients when compared with bipolar and tripolar equivalents.en_US
dc.subjectCardiac resynchronization therapy (CRT)en_US
dc.subjectDevice programminen_US
dc.subjectLeft ventricular leadsen_US
dc.titleAdditional electrodes on the Quartet™ LV lead provide more programmable pacing options than bipolar and tripolar equivalentsen_US
dc.typeJournal Articleen_US
dc.identifier.affiliationKerckhoff Klinik GmbH, Bad Nauheim, Germanyen_US
dc.identifier.affiliationMontreal Heart Institute, Montreal, Québec, Canadaen_US
dc.identifier.affiliationGuy's and St Thomas' Hospitals, London, UKen_US
dc.identifier.affiliationDepartment of Arrhythmology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italyen_US
dc.identifier.affiliationHerz- und Diabeteszentrum NRW, Bad Oeynhausen, Germanyen_US
dc.identifier.affiliationCHU Pontchaillou, Rennes, Franceen_US
dc.identifier.affiliationSt Jude Medical, Inc., Sylmar, CA, USAen_US
dc.identifier.affiliationBaptist Health, Lexington, KY, USAen_US
dc.type.austinJournal Articleen_US'Donnell, David
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
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