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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16653
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dc.contributor.authorGupta, Veer Bala-
dc.contributor.authorHone, Eugene-
dc.contributor.authorPedrini, Steve-
dc.contributor.authorDoecke, James-
dc.contributor.authorO'Bryant, Sid-
dc.contributor.authorJames, Ian-
dc.contributor.authorBush, Ashley I-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorAmes, David-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorAIBL Research Group-
dc.date2017-04-23-
dc.date.accessioned2017-05-24T02:03:05Z-
dc.date.available2017-05-24T02:03:05Z-
dc.date.issued2017-04-23-
dc.identifier.citationAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017; 8: 60-72en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16653-
dc.description.abstractINTRODUCTION: A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpensive and accessible first step for routine testing. METHODS: We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort. RESULTS: Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (P = .0003) and chemokine-309 (I-309) were increased in AD patients compared to mild cognitive impaired individuals over 36 months (P = .0008). DISCUSSION: These data suggest that apoJ may have potential in the context of use (COU) of AD diagnostics, I-309 may be specifically useful in the COU of identifying individuals at greatest risk for progressing toward AD. This work takes an initial step toward identifying blood biomarkers with potential use in the diagnosis and prognosis of AD and should be validated across other prospective cohorts.en
dc.subjectAlzheimer's diseaseen
dc.subjectBiomarkersen
dc.subjectBlooden
dc.titleAltered levels of blood proteins in Alzheimer's disease longitudinal study: results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohorten
dc.typeJournal Articleen
dc.identifier.journaltitleAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoringen
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationCo-operative Research Centre for Mental Health, Carlton, Victoria, Australiaen
dc.identifier.affiliationCSIRO Health and Biosecurity/Australian E-Health Research Centre, Brisbane, Queensland, Australiaen
dc.identifier.affiliationInstitute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USAen
dc.identifier.affiliationSchool of Engineering and Information Technology, Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australiaen
dc.identifier.affiliationThe Florey Institute, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australiaen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old age, St. George's Hospital, The University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSchool of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, Western Australia, Australiaen
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28508031en
dc.identifier.doi10.1016/j.dadm.2017.04.003en
dc.type.contentTexten
dc.identifier.orcid0000-0003-3910-2453en
dc.type.austinJournal Articleen_US
local.name.researcherMasters, Colin L
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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