Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16641
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dc.contributor.authorMyers, Kenneth A-
dc.contributor.authorMandelstam, Simone A-
dc.contributor.authorRamantani, Georgia-
dc.contributor.authorRushing, Elisabeth J-
dc.contributor.authorde Vries, Bert B A-
dc.contributor.authorKoolen, David A-
dc.contributor.authorScheffer, Ingrid E-
dc.date2017-04-25-
dc.date.accessioned2017-05-04T01:47:43Z-
dc.date.available2017-05-04T01:47:43Z-
dc.date.issued2017-04-25-
dc.identifier.citationEpilepsia 2017; online first: 25 Aprilen_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16641-
dc.description.abstractOBJECTIVE: This study was designed to describe the spectrum of epilepsy phenotypes in Koolen-de Vries syndrome (KdVS), a genetic syndrome involving dysmorphic features, intellectual disability, hypotonia, and congenital malformations, that occurs secondary to 17q21.31 microdeletions and heterozygous mutations in KANSL1. METHODS: We were invited to attend a large gathering of individuals with KdVS and their families. While there, we recruited individuals with KdVS and seizures, and performed thorough phenotyping. Additional subjects were included who approached us after the family support group brought attention to our research via social media. Inclusion criteria were genetic testing results demonstrating 17q21.31 deletion or KANSL1 mutation, and at least one seizure. RESULTS: Thirty-one individuals were studied, aged 2-35 years. Median age at seizure onset was 3.5 years, and 9 of 22 had refractory seizures 2 years after onset. Focal impaired awareness seizures were the most frequent seizure type occurring in 20 of 31, usually with prominent autonomic features. Twenty-one patients had prolonged seizures and, at times, refractory status epilepticus. Electroencephalography (EEG) showed focal/multifocal epileptiform discharges in 20 of 26. MRI studies of 13 patients were reviewed, and all had structural anomalies. Corpus callosum dysgenesis, abnormal hippocampi, and dilated ventricles were the most common, although periventricular nodular heterotopia, focal cortical dysplasia, abnormal sulcation, and brainstem and cerebellum abnormalities were also observed. One patient underwent epilepsy surgery for a lesion that proved to be an angiocentric glioma. SIGNIFICANCE: The typical epilepsy phenotype of KdVS involves childhood-onset focal seizures that are prolonged and have prominent autonomic features. Multifocal epileptiform discharges are the typical EEG pattern. Structural brain abnormalities may be universal, including signs of abnormal neuroblast migration and abnormal axonal guidance. Epilepsy surgery should be undertaken with care given the widespread neuroanatomic abnormalities; however, tumors are a rare, yet important, occurrence.en_US
dc.subjectKANSL1en_US
dc.subjectBrain malformationen_US
dc.subjectCorpus callosumen_US
dc.subjectEpilepsyen_US
dc.subjectKoolen-de Vries syndromeen_US
dc.subjectPeriventricular nodular heterotopiaen_US
dc.titleThe epileptology of Koolen-de Vries syndrome: Electro-clinico-radiologic findings in 31 patientsen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleEpilepsiaen_US
dc.identifier.affiliationDepartment of Medicine, Epilepsy Research Centre, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationSection of Neurology, Department of Pediatrics, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canadaen_US
dc.identifier.affiliationDepartment of Paediatrics, The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Radiology, The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDivision of Child Neurology, University Children's Hospital, Zurich, Switzerlanden_US
dc.identifier.affiliationSwiss Epilepsy Center, Zurich, Switzerlanden_US
dc.identifier.affiliationDepartment of Neuropathology, University Hospital, Zurich, Switzerlanden_US
dc.identifier.affiliationDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlandsen_US
dc.identifier.affiliationDepartment of Neurology, Royal Children's Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28440867en_US
dc.identifier.doi10.1111/epi.13746en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-7831-4593en_US
dc.identifier.orcid0000-0002-7931-2327en_US
dc.identifier.orcid0000-0002-2311-2174en_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptEpilepsy Research Centre-
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