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dc.contributor.authorRiddiough, Georgina E-
dc.contributor.authorHornby, Steve T-
dc.contributor.authorAsadi, Khashayar-
dc.contributor.authorAly, Ahmed-
dc.identifier.citationInternational Journal of Surgery Case Reports 2017; 30: 205-214en
dc.description.abstractBACKGROUND: Ectopic gastric mucosa (EGM) otherwise termed gastric heterotopia or gastric inlet patch occurs in approximately 2.5% of the population. Adenocarcinoma uncommonly involves the upper oesophagus, rarely arising from gastric heterotopia or submucosal glands. Currently, there are 58 cases in the literature of oesophageal adenocarcinoma arising within areas of EGM. To date no paper has differentiated between gastric or intestinal type adenocarcinoma. This case, which describes adenocarcinoma arising within EGM, exhibited a different immunophenotype reminiscent of gastric type glands, in the absence of intestinal metaplasia. This case should be regarded as a different type of carcinoma, consistent with a non-Barrett's oesophagus-associated adenocarcinoma. CLINICAL PRESENTATION: A 63year old female presented with a three month history of progressive cervical dysphagia with no associated weight loss or general malaise. Gastroscopy revealed a suspicious lesion at the cricopharyngeus. Positron emission tomography demonstrated a metabolically active primary lesion without evidence of distant disease. The patient received neo-adjuvant chemotherapy followed by a three stage total oesophagectomy. Histology demonstrated a moderately differentiated adenocarcinoma with gastric immunophenotype and background changes of gastric heterotopia. CONCLUSION: EGM is common but scarcely biopsied for evidence of dysplasia or adenocarcinoma. Whilst malignant progression is rare it is important that endoscopists are aware of the potential. Determining the exact type of adenocarcinoma may have implications for therapeutic approaches. Recognition of EGM at endoscopy may identify patients at greater risk of developing adenocarcinomas of the proximal oesophagus, however, this relationship and the necessity for screening requires more study.en
dc.subjectEctopic gastric mucosaen
dc.subjectGastric inlet patchen
dc.subjectOeosphageal canceren
dc.titleGastric adenocarinoma of the upper oesophagus: a literature review and case reporten
dc.typeJournal Articleen
dc.identifier.journaltitleInternational Journal of Surgery Case Reportsen
dc.identifier.affiliationDepartment of Upper GI Surgery, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Pathology, Austin Health, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Articleen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext- (University of Melbourne)-
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