Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16523
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMacIsaac, Richard J-
dc.contributor.authorJerums, George-
dc.contributor.authorEkinci, Elif I-
dc.date.accessioned2017-01-17T00:43:33Z-
dc.date.available2017-01-17T00:43:33Z-
dc.date.issued2016-10-
dc.identifier.citationAnnals of Translational Medicine 2016; 4(20): 409en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16523-
dc.description.abstractCardiovascular (CV) and kidney disease are common and significant complications in people with type 2 diabetes (T2DM). CV disease is the leading cause of death, morbidly and hospitalisations for people with T2DM. Furthermore, diabetic kidney disease is a major risk factor for CV disease and is the main reason why patients need renal replacement therapy. In this perspective, we highlight the results of the recent landmark EMPA-REG OUTCOME trial which has shown that empagliflozin, a member of the sodium-glucose co-transporter 2 (SGLT-2) inhibitor class of glucose lowering medications, reduces death from CV causes, hospitalisation for heart failure and progression to end stage kidney disease in patients with T2DM and established CV disease. The SGLT2 receptor mediates high-capacity glucose uptake in the early proximal tubule, and SGLT2 inhibitors, via their ability to promote glycosuria, have been developed as glucose lowering medications. As well as having a glucose lowering effect, SGLT-2 inhibitors also reduce blood pressure, promote weight loss and reduce uric acid levels. Potential side-effects or concerns related to the use of SGLT-2 inhibitors include increased rates of urinary tract infections, genital tract infections, postural hypotension, diabetic ketoacidosis, acute kidney injury and possible increased rates of fractures. The exact mechanisms that result in empagliflozin's dramatic CV and renal protective effects, with a very favourable safety/tolerability profile, in the EMPA-REG study remain to be fully defined. However, they are most likely distinct from the glucose lowering effects of empagliflozin. CV safety trials involving dapagliflozin and canagliflozin, members of the SGLT-2 class, are under way and the results from these studies will help to answer the question as to whether the cardio-renal benefits of empagliflozin are a class-effect or not. Without doubt, trials to investigate whether SGLT-2 inhibitors have cardio-renal protective effects in patients without diabetes will start soon.en_US
dc.subjectEmpagliflozinen_US
dc.subjectSGLT-2 inhibitorsen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectDiabetesen_US
dc.subjectDiabetic kidney diseaseen_US
dc.titleCardio-renal protection with empagliflozinen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAnnals of Translational Medicineen_US
dc.identifier.affiliationDepartment of Endocrinology & Diabetes, St Vincent’s Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationEndocrine Centre, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/27867961en_US
dc.identifier.doi10.21037/atm.2016.10.36en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherEkinci, Elif I
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

28
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.