Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16522
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dc.contributor.authorAlchin, David R-
dc.contributor.authorMurphy, Declan-
dc.contributor.authorLawrentschuk, Nathan-
dc.date2016-12-22-
dc.date.accessioned2017-01-17T00:42:49Z-
dc.date.available2017-01-17T00:42:49Z-
dc.date.issued2017-10-
dc.identifier.citationMinerva Urologica e Nefrologica 2017; 69(5): 459-465en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16522-
dc.description.abstractINTRODUCTION: Gleason score discordance can confound optimal treatment allocation of patients diagnosed with prostate cancer and place these patients at risk of worse oncological outcomes. Its prevalence remains endemic; its exact causation remains unknown. The objective of this review was to examine the observational studies of patient cohorts who have undergone radical prostatectomy with the aim of identifying any preoperative variables that may be associated with an upgrade in final prostatectomy Gleason score. EVIDENCE ACQUISITION: A non-systematic review of English articles from 2010 to present was performed through a MEDLINE search. Search terms included Gleason score, pathological, upgrade and radical prostatectomy. EVIDENCE SYNTHESIS: All studies included for review were retrospective analyses of radical prostatectomy series that examined factors associated with Gleason score discordance. CONCLUSIONS: The various studies found that Gleason score upgrading remains highly prevalent, and that some association can be seen with greater percent positive cores, longer biopsy core lengths, smaller prostate glands, higher percent tumour volume per gland, PSA density and visible lesions on mp-MRI.en_US
dc.titleRisk factors for Gleason score upgrading following radical prostatectomy: a review of the current literatureen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleMinerva Urologica e Nefrologicaen_US
dc.identifier.affiliationDepartment of Surgical Oncology, University of Melbourne, Peter MacCallum Cancer Centre, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, The University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28008754en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-8553-5618en_US
dc.identifier.orcidAustin Health, Heidelberg, Victoria, Australia-
dc.type.austinJournal Articleen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
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