Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/16404
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wlodarczyk, John | - |
dc.contributor.author | Ajani, Andrew E | - |
dc.contributor.author | Kemp, Dante | - |
dc.contributor.author | Andrianopoulos, Nick | - |
dc.contributor.author | Brennan, Angela L | - |
dc.contributor.author | Duffy, Stephen J | - |
dc.contributor.author | Clark, David J | - |
dc.contributor.author | Reid, Christopher M | - |
dc.date | 2015-07-15 | - |
dc.date.accessioned | 2016-11-03T05:39:49Z | - |
dc.date.available | 2016-11-03T05:39:49Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | Heart, Lung and Circulation 2016; 25(2): 107-117 | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/16404 | - |
dc.description.abstract | BACKGROUND: Major bleeding is a serious complication of percutaneous coronary intervention (PCI). We set out to investigate the incidence of major bleeding and its impact on hospitalisation and long-term mortality. METHOD: We examined seven years of registry data encompassing 16,860 PCI procedures. RESULTS: Between 2005 and 2011 major bleeding increased from 1.3% to 3.4%. In patients with ST elevated myocardial infarction (STEMI), the rate increased from 2.3% to 6.4%. The increase remained significant after adjusting for patient and procedural characteristics (OR=1.09/year, p=0.001). Bleeding risk was highest in patients presenting with out-of-hospital cardiac arrest and cardiogenic shock (CS). Women, STEMI patients, those aged over 70yrs or weighing <60kg were at higher risk. Glycoprotein IIb/IIIa-inhibitor use more than doubled the risk of bleeding (OR=2.28, p=<0.001). Mortality rates at one year were 4.18% overall and 7.9% in STEMI. Bleeding was a strong predictor of mortality after adjusting for potential confounders (HR=2.92, 95% CI: 2.08, 4.09). Bleeding significantly increased length of stay (med four days vs seven days) and rehospitalisation at 12 months (OR=1.36, 95% CI: 1.08, 1.70). CONCLUSIONS: Major bleeding rates post-PCI appear to be increasing in Australia. Bleeding increases hospitalisation and is associated with poor clinical outcomes. | en_US |
dc.subject | Percutaneous coronary intervention | en_US |
dc.subject | Bleeding | en_US |
dc.subject | Hospitalisation | en_US |
dc.subject | Mortality | en_US |
dc.subject | PCI | en_US |
dc.subject | STEMI | en_US |
dc.title | Incidence, predictors and outcomes of major bleeding in patients following percutaneous coronary interventions in Australia | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Heart, Lung and Circulation | en_US |
dc.identifier.affiliation | John Wlodarczyk Consulting Services, Newcastle, NSW, Australia | en_US |
dc.identifier.affiliation | Monash University, Melbourne,Victoria, Australia | en_US |
dc.identifier.affiliation | Monash Centre of Cardiovascular Research & Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Melbourne, Victoria, Australia | en_US |
dc.identifier.affiliation | Royal Melbourne Hospital, Parkville, Victoria, Australia | en_US |
dc.identifier.affiliation | Alfred Hospital, Melbourne, Victoria, Australia | en_US |
dc.identifier.affiliation | Austin Health, Heidelberg, Victoria, Australia | en_US |
dc.identifier.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/26320074 | en_US |
dc.identifier.doi | 10.1016/j.hlc.2015.06.826 | en_US |
dc.type.content | Text | en_US |
dc.type.austin | Journal Article | en_US |
local.name.researcher | Clark, David J | |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Cardiology | - |
crisitem.author.dept | University of Melbourne Clinical School | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.