Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16374
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dc.contributor.authorSuzuki, Satoshi-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorGoodwin, Mark D-
dc.contributor.authorNoë, Geertje D-
dc.contributor.authorSmith, Paul E-
dc.contributor.authorGlassford, Neil-
dc.contributor.authorSchneider, Antoine G-
dc.contributor.authorBellomo, Rinaldo-
dc.date.accessioned2016-10-19T04:19:33Z-
dc.date.available2016-10-19T04:19:33Z-
dc.date.issued2015-12-
dc.identifier.citationJournal of Critical Care 2015; 30(6): 1232-1237en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16374-
dc.description.abstractPURPOSE: The purpose of the study is to assess the effect of a conservative oxygen therapy (COT) (target SpO2 of 90%-92%) on radiological atelectasis and mechanical ventilation modes. MATERIALS AND METHODS: We conducted a secondary analysis of 105 intensive care unit patients from a pilot before-and-after study. The primary outcomes of this study were changes in atelectasis score (AS) of 555 chest radiographs assessed by radiologists blinded to treatment allocation and time to weaning from mandatory ventilation and first spontaneous ventilation trial (SVT). RESULTS: There was a significant difference in overall AS between groups, and COT was associated with lower time-weighted average AS. In addition, in COT patients, change from mandatory to spontaneous ventilation or time to first SVT was shortened. After adjustment for baseline characteristics and interactions between oxygen therapy, radiological atelectasis, and mechanical ventilation management, patients in the COT group had significantly lower "best" AS (adjusted odds ratio, 0.28 [95% confidence interval {CI}, 0.12-0.66]; P=.003) and greater improvement in AS in the first 7 days (adjusted odds ratio, 0.42 [95% CI, 0.17-0.99]; P=.049). Moreover, COT was associated with significantly earlier successful weaning from a mandatory ventilation mode (adjusted hazard ratio, 2.96 [95% CI, 1.73-5.04]; P<.001) and with shorter time to first SVT (adjusted hazard ratio, 1.77 [95% CI, 1.13-2.78]; P=.013). CONCLUSIONS: In mechanically ventilated intensive care unit patients, COT might be associated with decreased radiological evidence of atelectasis, earlier weaning from mandatory ventilation modes, and earlier first trial of spontaneous ventilation.en_US
dc.subjectAtelectasisen_US
dc.subjectCritical illnessen_US
dc.subjectHyperoxiaen_US
dc.subjectMechanical ventilationen_US
dc.subjectOxygenen_US
dc.subjectOxygen inhalation therapyen_US
dc.titleAtelectasis and mechanical ventilation mode during conservative oxygen therapy: a before-and-after studyen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Critical Careen_US
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Radiology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/26346814en_US
dc.identifier.doi10.1016/j.jcrc.2015.07.033en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptRadiology-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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