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dc.contributor.authorTeichtahl, Andrew J-
dc.contributor.authorWluka, Anita E-
dc.contributor.authorWang, Y-
dc.contributor.authorWijethilake, PN-
dc.contributor.authorStrauss, Boyd J-
dc.contributor.authorProietto, Joseph-
dc.contributor.authorDixon, John B-
dc.contributor.authorJones, G-
dc.contributor.authorForbes, A-
dc.contributor.authorCicuttini, Flavia M-
dc.identifier.citationOsteoarthritis and Cartilage 2015; 23(12): 2150-2157en_US
dc.description.abstractBACKGROUND: There is growing interest in the role of intramuscular fat and how it may influence clinical outcomes. Vastus medialis (VM) is a functionally important quadriceps muscle that helps to stabilise the knee joint. This longitudinal study examined the determinants of VM fat infiltration and whether VM fat infiltration influenced knee cartilage volume. METHODS: 250 participants without any diagnosed arthropathy were assessed at baseline between 2005 and 2008, and 197 participants at follow-up between 2008 and 2010. Ambulatory and sporting activity were assessed and magnetic resonance imaging (MRI) was used to determine knee cartilage volume and VM fat infiltration. RESULTS: Age, female gender, BMI and weight were positively associated with baseline VM fat infiltration (P ≤ 0.03), while ambulatory and sporting activity were negatively associated with VM fat infiltration (P ≤ 0.05). After adjusting for confounders, a reduction in VM fat infiltration was associated with a reduced annual loss of medial tibial (β = -10 mm(3); 95% CI -19 to 0 mm(3); P = 0.04) and patella (β = -18 mm(3); 95% CI -36 to 0 mm(3); P = 0.04) cartilage volume. CONCLUSION: This community-based study of healthy adults has shown that VM fat infiltration can be modified by lifestyle factors including weight loss and exercise, and reducing fat infiltration in VM has beneficial effect on knee cartilage preservation. The findings suggest that modifying VM fat infiltration via lifestyle interventions may have the potential to reduce the risk of knee OA.en_US
dc.titleVastus medialis fat infiltration – a modifiable determinant of knee cartilage lossen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleOsteoarthritis and Cartilageen_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationBaker IDI Heart and Diabetes Institute, Commercial Road, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, Monash University, Clayton, Victoria, Australiaen_US
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationMenzies Research Institute, Hobart, Tasmania, Australiaen_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article- (University of Melbourne)-
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