Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13713
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dc.contributor.authorZhang, L-
dc.contributor.authorTanaka, A-
dc.contributor.authorZhu, G-
dc.contributor.authorBaldwin, Ian C-
dc.contributor.authorEastwood, Glenn-
dc.contributor.authorBellomo, Rinaldo-
dc.date2016-
dc.date.accessioned2015-12-22T22:45:44Z
dc.date.accessioned2015-12-22T22:45:28Z
dc.date.available2015-12-22T22:45:28Z
dc.date.available2015-12-22T22:45:44Z
dc.date.issued2016-
dc.identifier.citationBlood Purification 2016, vol. 41(4) p. 254-263en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13713-
dc.description.abstractBackground: We aimed to describe the previously unstudied relationship between circuit pressures and circuit clotting, here labeled as ‘artificial kidney failure' (AKF), in patients receiving continuous renal replacement therapy (CRRT). Methods: We performed an observational study of CRRT-treated critically ill patients to continuously record the multiple CRRT circuit pressures. Results: Three patterns of access outflow dysfunction (AOD) were also noted: severe, moderate and mild. Compared with circuits without AOD, circuits experiencing at least one AOD episode had shorter lifespans (14.2 ± 12.7 vs. 21.3 ± 16.5 h, p = 0.057). This effect was more obvious with moderate or severe AOD (8.7 ± 4.6 vs. 20.6 ± 15.7 h, p = 0.007). If any AOD events occurred within the first 4 h, the sensitivity and specificity in predicting early-immediate AKF were 53.4 and 94.4%, respectively. Conclusions: Early and intermediate AKF during CRRT is most likely dependent on AOD, which is a frequent event with variable severity.en_US
dc.subjectRenal replacement therapyen_US
dc.subjectObservational studyen_US
dc.subjectKidneys, artificialen_US
dc.titlePatterns and mechanisms of artificial kidney failure during continuous renal replacement therapyen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBlood Purificationen_US
dc.identifier.affiliationDepartment of Intensive Care Unit, Austin Hospital, Heidelberg, Australiaen_US
dc.identifier.doi10.1159/000441968en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherBaldwin, Ian C
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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