Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13702
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dc.contributor.authorYoung, P-
dc.contributor.authorSaxena, M-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorFreebairn, R-
dc.contributor.authorHammond, N-
dc.contributor.authorvan Haren, F-
dc.contributor.authorHolliday, M-
dc.contributor.authorHenderson, S-
dc.contributor.authorMackle, D-
dc.contributor.authorMcArthur, C-
dc.contributor.authorMcGuinness, S-
dc.contributor.authorMyburgh, J-
dc.contributor.authorWeatherall, M-
dc.contributor.authorWebb, S-
dc.contributor.authorBeasley, R-
dc.contributor.authorHEAT Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group-
dc.date2015-10-05-
dc.date.accessioned2015-11-05T01:41:41Z-
dc.date.accessioned2015-11-05T02:45:49Z-
dc.date.available2015-11-05T01:41:41Z-
dc.date.available2015-11-05T02:45:49Z-
dc.date.issued2015-12-03-
dc.identifier.citationThe New England Journal of Medicine 2015; 373(23): 2215-2224en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13702-
dc.description.abstractBackground Acetaminophen is a common therapy for fever in patients in the intensive care unit (ICU) who have probable infection, but its effects are unknown. Methods We randomly assigned 700 ICU patients with fever (body temperature, ≥38°C) and known or suspected infection to receive either 1 g of intravenous acetaminophen or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial therapy, or death. The primary outcome was ICU-free days (days alive and free from the need for intensive care) from randomization to day 28. Results The number of ICU-free days to day 28 did not differ significantly between the acetaminophen group and the placebo group: 23 days (interquartile range, 13 to 25) among patients assigned to acetaminophen and 22 days (interquartile range, 12 to 25) among patients assigned to placebo (Hodges-Lehmann estimate of absolute difference, 0 days; 96.2% confidence interval [CI], 0 to 1; P=0.07). A total of 55 of 345 patients in the acetaminophen group (15.9%) and 57 of 344 patients in the placebo group (16.6%) had died by day 90 (relative risk, 0.96; 95% CI, 0.66 to 1.39; P=0.84). Conclusions Early administration of acetaminophen to treat fever due to probable infection did not affect the number of ICU-free days. (Funded by the Health Research Council of New Zealand and others; HEAT Australian New Zealand Clinical Trials Registry number, ACTRN12612000513819 .).en_US
dc.subjectAcetaminophenen_US
dc.subjectFeveren_US
dc.subjectIntensive Care Unitsen_US
dc.titleAcetaminophen for fever in critically ill patients with suspected infectionen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleThe New England Journal of Medicineen_US
dc.identifier.affiliationIntensive Care Unit, Wellington Regional Hospitalen_US
dc.identifier.affiliationMedical Research Institute of New Zealanden_US
dc.identifier.affiliationWellington School of Medicine, University of Otagoen_US
dc.identifier.affiliationIntensive Care Unit, Hawke's Bay Hospital, Hastingsen_US
dc.identifier.affiliationChristchurch Hospital, Christchurchen_US
dc.identifier.affiliationAuckland City Hospitalen_US
dc.identifier.affiliationCritical Care and Trauma Division, George Institute for Global Health, Sydneyen_US
dc.identifier.affiliationIntensive Care Unit, St. George Hospital, Kogarahen_US
dc.identifier.affiliationMalcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St. Leonardsen_US
dc.identifier.affiliationFaculty of Medicine, St. George Clinical School, University of New South Wales, Kensington, NSWen_US
dc.identifier.affiliationIntensive Care Unit, Austin Hospitalen_US
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash Universityen_US
dc.identifier.affiliationFaculty of Medicine, University of Melbourneen_US
dc.identifier.affiliationIntensive Care Unit, Canberra Hospital, Canberra, ACTen_US
dc.identifier.affiliationIntensive Care Unit, Royal Perth Hospital, Perthen_US
dc.identifier.affiliationSchool of Medicine and Pharmacology, University of Western Australia, Crawleyen_US
dc.type.studyortrialClinical Trialen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/26436473en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
Appears in Collections:Journal articles
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