Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13627
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dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorJackson, Graeme Den
dc.contributor.authorKalnins, Renate Men
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T03:31:04Z
dc.date.available2015-05-16T03:31:04Z
dc.date.issued1998-11-01en
dc.identifier.citationEpilepsia; 39(11): 1174-81en
dc.identifier.govdoc9821981en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13627en
dc.description.abstractIn patients with refractory temporal lobe epilepsy, studies have suggested volume deficits measured by MRI of brain structures outside the epileptogenic hippocampus. Hippocampal sclerosis (HS) is a frequent, but not obligate, finding in such patients. The present study examines the influence of the presence of HS on quantitative magnetic resonance imaging (MRI) measurements.We analyzed 47 patients and 30 controls by quantitative MRI, including intracranial volume (ICV), hemicranial volume, hippocampal volume (HCV), and T2 relaxometry. MRI results were compared with histological findings in the resected temporal lobe.Histology documented HS in 35 patients (HS group) and other findings in 12 patients (no-HS group). In both groups, the hemicranial volume ipsilateral to the epileptogenic focus was significantly smaller than on the contralateral side (p < 0.004). The HCV on both sides was smaller in the HS group compared with patients without HS (p < or = 0.004). Unilateral hippocampal atrophy and increased T2 value were found in 71% of patients with HS, and bilaterally normal HCV and T2 value were found in 67% of patients without HS.The smaller hemicranial volume on the focus side, irrespective of the presence or absence of HS suggests a different pathogenic mechanism for the additional hemicranial volume deficit, compared to HS itself. The contralateral HCV deficit depends on the presence of HS, indicating a pathogenic connection between damage to both hippocampi.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAge of Onseten
dc.subject.otherBrain.anatomy & histology.pathologyen
dc.subject.otherBrain Diseases.pathologyen
dc.subject.otherEpilepsy, Temporal Lobe.diagnosis.pathologyen
dc.subject.otherFemaleen
dc.subject.otherHippocampus.pathologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherSclerosis.pathologyen
dc.titleHemicranial volume deficits in patients with temporal lobe epilepsy with and without hippocampal sclerosis.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsiaen
dc.identifier.affiliationDepartment of Neurology, and Brain Imaging Research Institute, Austin and Repatriation Medical Centre, University of Melbourne, Australiaen
dc.description.pages1174-81en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9821981en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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