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dc.contributor.authorZulli, Anthonyen
dc.contributor.authorBuxton, Brian Fen
dc.contributor.authorDoolan, Laurieen
dc.contributor.authorLiu, J Jen
dc.identifier.citationClinical Science 1998; 95(5): 589-93en
dc.description.abstract1. Patients with an elevated plasma level of either homocysteine or cholesterol are at increased risk of cardiovascular disease. Both methionine, the precursor of homocysteine, and cholesterol are found primarily in the same foods; therefore we investigated the effect of methionine feeding alone, cholesterol feeding alone, and both, on the thickness of the aortic wall and the aortic elastic lamina of normotensive animals.2. Twenty normotensive rats were divided into four groups of five animals. The following diet was administered for 15 weeks: normal chow; normal chow supplemented with 2% methionine; normal chow supplemented with 2% cholesterol; normal chow supplemented with 2% methionine+2% cholesterol.3. The results showed a 3-fold decrease (P<0.003) in the aortic elastic lamina in the 2% methionine group and a 2.5-fold decrease in the 2% cholesterol group compared with the normal chow group. There was a 9-fold (P<0.0003) decrease in the 2% methionine+2% cholesterol group compared with the normal chow group. Furthermore, feeding with methionine plus cholesterol significantly increased aortic wall thickness compared with the methionine group, cholesterol group or control.4. These results demonstrate an augmented effect of cholesterol plus methionine in the deterioration of the aortic elastic lamina, and furthermore, the combination of these two agents increases the thickness of the aortic wall. The results indicate a more important role for these two agents in combination than for either agent alone.en
dc.subject.otherAnalysis of Varianceen
dc.subject.otherAorta.anatomy & histology.drug effectsen
dc.subject.otherCardiovascular Diseases.etiologyen
dc.subject.otherCholesterol.administration & dosage.blooden
dc.subject.otherDrug Synergismen
dc.subject.otherElastic Tissue.anatomy & histology.drug effectsen
dc.subject.otherMethionine.administration & dosageen
dc.subject.otherRats, Inbred WKYen
dc.titleAugmented effects of methionine and cholesterol in decreasing the elastic lamina while thickening the aortic wall in the rat aorta.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical Scienceen
dc.identifier.affiliationVascular Biology Unit, Department of Cardiac Surgery, University of Melbourne Austin Hospital, Heidelberg, Victoria 3084, Australiaen
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Surgery-
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