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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Burrell, Louise M | en |
dc.contributor.author | Phillips, P A | en |
dc.contributor.author | Risvanis, John | en |
dc.contributor.author | Chan, Robert K | en |
dc.contributor.author | Aldred, K L | en |
dc.contributor.author | Johnston, Colin I | en |
dc.date.accessioned | 2015-05-16T03:30:16Z | |
dc.date.available | 2015-05-16T03:30:16Z | |
dc.date.issued | 1998-07-01 | en |
dc.identifier.citation | The American Journal of Physiology; 275(1 Pt 2): H176-82 | en |
dc.identifier.govdoc | 9688911 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/13616 | en |
dc.description.abstract | The hormone arginine vasopressin (AVP) contributes to water retention and vasoconstriction in congestive heart failure (CHF) through effects at the V2 and V1a receptors, respectively. The effect of long-term V2 receptor (V2R) blockade using OPC-31260 was assessed in a rat model of postinfarction-induced CHF. Rats underwent coronary artery ligation or sham operation and were treated for 6 mo with oral OPC-31260 (10 mg . kg-1 . day-1) or vehicle. CHF was characterized by left ventricular remodeling and impaired systolic function, increased cardiac and lung weight, and elevated plasma atrial natriuretic peptide; plasma AVP and plasma renin activity were not increased. Chronic V2R blockade increased urine volume (P < 0.01) and decreased urine osmolality (P < 0.01) but had no natriuretic effects. V2R blockade did not activate the renin-angiotensin system but increased plasma AVP in CHF (P < 0.01). V2R blockade did not influence cardiac remodeling, cardiac function, or survival. These results suggest that AVP plays a major role in water retention through the renal V2R in a rat model of CHF. V2R blockade using OPC-31260 may represent an alternative to standard diuretic therapy in the management of water retention that characterizes heart failure. | en |
dc.language.iso | en | en |
dc.subject.other | Animals | en |
dc.subject.other | Antidiuretic Hormone Receptor Antagonists | en |
dc.subject.other | Arginine Vasopressin.blood | en |
dc.subject.other | Benzazepines.pharmacology | en |
dc.subject.other | Blood Pressure.drug effects | en |
dc.subject.other | Body Weight.drug effects | en |
dc.subject.other | Diuresis.drug effects | en |
dc.subject.other | Female | en |
dc.subject.other | Heart.drug effects.physiopathology | en |
dc.subject.other | Heart Failure.etiology.physiopathology | en |
dc.subject.other | Hemodynamics.drug effects.physiology | en |
dc.subject.other | Lung.drug effects.physiopathology | en |
dc.subject.other | Myocardial Infarction.complications.physiopathology | en |
dc.subject.other | Organ Size.drug effects | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Sprague-Dawley | en |
dc.subject.other | Renin-Angiotensin System | en |
dc.subject.other | Survival Analysis | en |
dc.subject.other | Systole | en |
dc.title | Long-term effects of nonpeptide vasopressin V2 antagonist OPC-31260 in heart failure in the rat. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | American Journal of Physiology | en |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg 3084, Victoria, Australia | en |
dc.description.pages | H176-82 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/9688911 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Burrell, Louise M | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Cardiology | - |
crisitem.author.dept | General Medicine | - |
crisitem.author.dept | Medicine (University of Melbourne) | - |
crisitem.author.dept | Cardiology | - |
Appears in Collections: | Journal articles |
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