Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13614
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dc.contributor.authorCooper, Mark Een
dc.date.accessioned2015-05-16T03:30:08Z
dc.date.available2015-05-16T03:30:08Z
dc.date.issued1998-07-18en
dc.identifier.citationLancet (london, England); 352(9123): 213-9en
dc.identifier.govdoc9683226en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13614en
dc.description.abstractIt is likely that the pathophysiology of diabetic nephropathy involves an interaction of metabolic and haemodynamic factors. Relevant metabolic factors include glucose-dependent pathways such as advanced glycation, increased formation of polyols, and activation of the enzyme, protein kinase C. Specific inhibitors of the various pathways are now available, enabling investigation of the role of these processes in the pathogenesis of diabetic nephropathy and potentially to provide new therapeutic approaches for the prevention and treatment of diabetic nephropathy. Haemodynamic factors to consider include systemic hypertension, intraglomerular hypertension, and the role of vasoactive hormones, such as angiotensin II. The mainstay of therapy remains attaining optimum glycaemic control. Antihypertensive therapy has a major role in slowing the progression of diabetic nephropathy. Agents that interrupt the renin-angiotensin system such as angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists may be particularly useful as renoprotective agents in both the hypertensive and normotensive context.en
dc.language.isoenen
dc.subject.otherDiabetes Mellitus, Type 1.complicationsen
dc.subject.otherDiabetes Mellitus, Type 2.complicationsen
dc.subject.otherDiabetic Nephropathies.epidemiology.etiology.prevention & control.therapyen
dc.subject.otherHumansen
dc.subject.otherKidney.physiopathologyen
dc.subject.otherRisk Factorsen
dc.titlePathogenesis, prevention, and treatment of diabetic nephropathy.en
dc.typeJournal Articleen
dc.identifier.journaltitleLanceten
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin and Repatriation Medical Centre (Repatriation Campus), West Heidelberg, VIC, Australiaen
dc.identifier.doi10.1016/S0140-6736(98)01346-4en
dc.description.pages213-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9683226en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
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