Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13610
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dc.contributor.authorJackson, Graeme Den
dc.contributor.authorMcIntosh, A Men
dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T03:29:50Z
dc.date.available2015-05-16T03:29:50Z
dc.date.issued1998-07-01en
dc.identifier.citationNeurology; 51(1): 78-84en
dc.identifier.govdoc9674783en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13610en
dc.description.abstractTo test both the genetic and acquired hypotheses for the etiology of hippocampal sclerosis (HS) by studying with optimized and quantitative MRI three monozygous (MZ) twin pairs in which the index twin had temporal lobe epilepsy and HS.There is conflicting evidence in the literature regarding whether HS is genetic or acquired prenatally, perinatally, or as a consequence of prolonged childhood seizures.We compared three MZ pairs with 30 age-matched control subjects who had no history of a neurologic disorder; we also used the twins as matched samples to assess subtle differences between the affected and the unaffected twins.All of the affected twins had prolonged seizures with fever in early childhood, which stood out as the unique factor common to all affected twins and was absent in all the unaffected twins. HS was present in all affected twins but was absent in the unaffected twin on visual, volumetric, and T2 relaxometry criteria. Comparison of the affected twin with the co-twin revealed that intracranial volume ipsilateral to the HS was relatively small in two of three affected twins.The absence of HS in the unaffected twin is strong evidence against a genetic hypothesis for HS. Neither perinatal problems nor birth order were factors in determining the presence of HS. This twin study supports the notion of HS as an acquired lesion secondary to prolonged seizures in early childhood and suggests that regional abnormalities of intracranial volume are associated with HS.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherBirth Orderen
dc.subject.otherEpilepsy, Temporal Lobe.diagnosis.pathologyen
dc.subject.otherFemaleen
dc.subject.otherHippocampus.pathologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherSclerosisen
dc.subject.otherTwins, Monozygoticen
dc.titleHippocampal sclerosis studied in identical twins.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationCentre for Brain Imaging Research and Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Victoria, Australiaen
dc.description.pages78-84en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9674783en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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