Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13516
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dc.contributor.authorStraznicky, N Een
dc.contributor.authorHowes, L Gen
dc.contributor.authorBarrington, V Een
dc.contributor.authorLam, Wen
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T03:23:15Z
dc.date.available2015-05-16T03:23:15Z
dc.date.issued1997-03-01en
dc.identifier.citationBlood Pressure; 6(2): 96-102en
dc.identifier.govdoc9105648en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13516en
dc.description.abstractTo examine the effects of short-term dietary lipid modification on alpha- and beta-adrenoceptor-mediated cardiovascular responsiveness, 19 normal volunteers consumed either a high-fat or a low-fat diet for 2 weeks in an open, randomized, crossover study of 6 weeks' duration. Diets were balanced for sodium and potassium content. Adrenoceptor-mediated cardiovascular responsiveness was assessed by measuring blood pressure and heart rate responses to incremental infusions of phenylephrine and isoprenaline. Baroreflexes were studied by examining heart rate responses to phenylephrine and to the Valsalva manoeuvre. Total plasma cholesterol and low-density lipoprotein cholesterol levels both fell significantly (by 22% and 26%, respectively), on the low-fat compared with the high-fat diet, as did resting supine blood pressures and heart rate (by 6 mmHg systolic and 3 mmHg diastolic, and 5 beats/min). These changes were accompanied by a significant reduction in the systolic blood pressure response to isoprenaline. Blood pressure responses to phenylephrine and baroreflex sensitivity did not change. These results suggest that dietary fat intake alters cardiac beta-adrenergic reactivity without significant effects on vascular alpha-adrenoceptor mediated responses or baroreflexes.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherBaroreflex.physiologyen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherBody Weighten
dc.subject.otherCardiovascular Physiological Phenomenaen
dc.subject.otherCross-Over Studiesen
dc.subject.otherDiet, Fat-Restricteden
dc.subject.otherFemaleen
dc.subject.otherHeart Rate.drug effectsen
dc.subject.otherHumansen
dc.subject.otherIsoproterenol.pharmacologyen
dc.subject.otherLipids.blooden
dc.subject.otherMaleen
dc.subject.otherPhenylephrine.pharmacologyen
dc.subject.otherReceptors, Adrenergic, alpha.physiologyen
dc.subject.otherReceptors, Adrenergic, beta.physiologyen
dc.subject.otherReference Valuesen
dc.subject.otherUrine.chemistryen
dc.titleEffects of dietary lipid modification on adrenoceptor-mediated cardiovascular responsiveness and baroreflex sensitivity in normotensive subjects.en
dc.typeJournal Articleen
dc.identifier.journaltitleBlood pressureen
dc.identifier.affiliationDepartment of Clinical Pharmacology and Therapeutics, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages96-102en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9105648en
dc.type.austinJournal Articleen
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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