Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13504
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dc.contributor.authorLiu, J Jen
dc.contributor.authorDoolan, Laurieen
dc.contributor.authorXie, Ben
dc.contributor.authorChen, J Ren
dc.contributor.authorBuxton, Brian Fen
dc.date.accessioned2015-05-16T03:22:25Z
dc.date.available2015-05-16T03:22:25Z
dc.date.issued1997-01-01en
dc.identifier.citationThe Journal of Thoracic and Cardiovascular Surgery; 113(1): 108-13en
dc.identifier.govdoc9011679en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13504en
dc.description.abstractMilrinone is an inotropic drug with vasodilator activity that has been shown to be useful in increasing cardiac output and decreasing wedge pressure. Despite these advantages, it is unknown whether this drug can be used for the treatment of perioperative spasm of coronary bypass grafts. This study was undertaken to investigate the in vitro vascular effect of milrinone on internal thoracic arteries obtained from patients undergoing coronary artery bypass grafting. The results showed that milrinone produced a potent, concentration-dependent, preventive effect on the norepinephrine-induced contraction of internal thoracic arteries, as well as reversing contraction of internal thoracic arteries by receptor-dependent agents, including the thromboxane A2 mimetic U46619, the vasoconstrictor peptide endothelin-1, and the alpha1-adrenal receptor agonist phenylephrine. The relaxing effect of milrinone was weaker, however, on internal thoracic arteries contracted with 25 mmol/L potassium chloride. Comparison of milrinone with other vasodilators, including papaverine, nitroprusside, and glyceryl trinitrate, showed milrinone to be more potent than papaverine but less potent than nitroprusside and glyceryl trinitrate. The inhibitory effect of milrinone on internal thoracic artery contraction appeared as a reduction in contractile force, not as an increase in the values of concentrations of the agonists causing 50% maximal contraction, which indicates that milrinone exerts its vasodilator effect directly on the smooth muscles, not on the membrane receptors. The results also showed no significant difference in relaxing effect between internal thoracic artery rings with and without endothelium. In conclusion, this study provides experimental evidence that milrinone is a potent, endothelium-independent, direct vasodilator of the human internal thoracic artery and provides the scientific rationale for a future clinical trial with this drug for the perioperative treatment of internal thoracic artery spasm in cardiac surgical patients.en
dc.language.isoenen
dc.subject.otherCoronary Artery Bypassen
dc.subject.otherHumansen
dc.subject.otherMilrinoneen
dc.subject.otherPyridones.pharmacologyen
dc.subject.otherThoracic Arteries.physiopathology.transplantationen
dc.subject.otherVasoconstrictionen
dc.subject.otherVasodilator Agents.pharmacologyen
dc.titleDirect vasodilator effect of milrinone, an inotropic drug, on arterial coronary bypass grafts. FANZCA .en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Journal of thoracic and cardiovascular surgeryen
dc.identifier.affiliationDepartment of Cardiac Surgery, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages108-13en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/9011679en
dc.type.austinJournal Articleen
local.name.researcherBuxton, Brian F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiac Surgery-
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