Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13481
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dc.contributor.authorAllen, Terri Jen
dc.contributor.authorCooper, Mark Een
dc.contributor.authorGilbert, Richard Een
dc.contributor.authorWinikoff, Jen
dc.contributor.authorSkinni, S Len
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-16T03:20:48Z
dc.date.available2015-05-16T03:20:48Z
dc.date.issued1996-09-01en
dc.identifier.citationKidney International; 50(3): 902-7en
dc.identifier.govdoc8872965en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13481en
dc.description.abstractSerum prorenin is increased in patients with insulin dependent diabetes mellitus (IDDM) with microvascular complications. The present longitudinal study investigated whether increases in serum total renin concentration (TRC, active+prorenin) can predict the development of microalbuminuria in IDDM patients over a 10 year period. TRC and albumin excretion rates (AER) were determined in 78 IDDM patients who were followed longitudinally for 10.4 +/- 0.2 (mean +/- SE) years. Twelve patients had progressively increasing albuminuria (progressors), and these were compared to 66 patients in whom albuminuria did not rise (non-progressors). The two groups had similar duration of diabetes, age, follow-up, glycemic control and blood pressure at the start of the study. Serum TRC was increased in progressors [350 (1.1) mIU/liter, geometric mean (tolerance factor)] compared to non-progressors [189 (1.2)] after 5 to 10 years duration of diabetes, and continued to rise in this group, reaching a mean of 923 mIU/liter (normal range 131 to 170) after 20 years of diabetes. When serial measurements of TRC and AER were compared in individual progressors, a significant increase in TRC was apparent up to five years before the onset of microalbuminuria. Microalbuminuria in patients with IDDM is preceded by a substantial increase in serum TRC, suggesting that serum TRC may predict the subsequent development of incipient nephropathy.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherAlbuminuria.blooden
dc.subject.otherChilden
dc.subject.otherChild, Preschoolen
dc.subject.otherCohort Studiesen
dc.subject.otherCross-Sectional Studiesen
dc.subject.otherDiabetes Mellitus, Type 1.blood.complications.urineen
dc.subject.otherDiabetic Nephropathies.blooden
dc.subject.otherDiabetic Retinopathy.blooden
dc.subject.otherDisease Progressionen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherHumansen
dc.subject.otherImmunoradiometric Assayen
dc.subject.otherLongitudinal Studiesen
dc.subject.otherMaleen
dc.subject.otherPredictive Value of Testsen
dc.subject.otherRenin.blooden
dc.subject.otherSensitivity and Specificityen
dc.titleSerum total renin is increased before microalbuminuria in diabetes.en
dc.typeJournal Articleen
dc.identifier.journaltitleKidney Internationalen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin & Repatriation Medical Centere, Heidelberg, Victoria, Australiaen
dc.description.pages902-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8872965en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptEndocrinology-
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