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Title: Angiotensin IV inhibits neurite outgrowth in cultured embryonic chicken sympathetic neurones.
Austin Authors: Moeller, I;Small, D H;Reed, G;Harding, J W;Mendelsohn, Frederick AO;Chai, Syn Y
Affiliation: Austin and Repatriation Medical Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 24-Jun-1996
Publication information: Brain Research; 725(1): 61-6
Abstract: Angiotensin IV (Val-Tyr-Ile-His-Pro-Phe) is reported to enhance apomorphine induced stereotypy and to improve memory recall through actions on specific binding sites in the central nervous system. In the present study, 10 nM angiotensin IV or angiotensin II inhibited neurite outgrowth from cultured E11 chicken paravertebral sympathetic neurones by 25%. The effects of both peptides were inhibited by a 1 microM concentration of the angiotensin IV analogues. WSU 4042, Nle1-Y-I-amide or Nle1-AIV, but not by the avian angiotensin II antagonists, [Sar1,Ile8]Ang II or CGP 42112, suggesting that the inhibition of neurite outgrowth by both peptides is mediated by the angiotensin IV binding site. These results suggest that angiotensin IV may be involved in neurite modelling and may therefore have an important role in neuronal development.
Gov't Doc #: 8828586
Type: Journal Article
Subjects: Angiotensin II.analogs & derivatives.pharmacology
Cells, Cultured.drug effects
Chick Embryo
Dose-Response Relationship, Drug
Neurites.drug effects
Sympathetic Nervous System.drug effects
Appears in Collections:Journal articles

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