Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13464
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dc.contributor.authorBurrell, Louise M-
dc.contributor.authorChan, R-
dc.contributor.authorPhillips, P A-
dc.contributor.authorCalafiore, Paul-
dc.contributor.authorTonkin, Andrew M-
dc.contributor.authorJohnston, Colin I-
dc.date.accessioned2015-05-16T03:19:08Z
dc.date.available2015-05-16T03:19:08Z
dc.date.issued1996-06-07-
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 23(6-7): 570-2en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13464en
dc.description.abstract1. The present study determined whether two dimensional guided M-mode echocardiography could assess left ventricular (LV) geometry and function following a moderate size myocardial infarction in the rat. 2. Myocardial infarction (MI) was induced by left coronary artery ligation and rats were studied 4 weeks later. Infarct rats showed increased LV internal diastolic diameter (7.33 +/- 0.8 vs 5.91 +/- 0.6 mm; P < 0.001), LV systolic diameter (3.73 +/- 1.2 vs 1.87 +/- 0.6 mm; P < 0.001) and thickening of the noninfarcted posterior wall compared with sham operated rats (1.81 +/- 0.2 vs 1.47 +/- 0.3; P < 0.001; n = 10/group; mean +/- s.d.). Systolic function was impaired in infarct rats who showed reduced fractional shortening (50 +/- 12 vs 68 +/- 9%; P < 0.001) and fractional area change (41 +/- 14 vs 78 +/- 5%; P < 0.001). Infarct size measured echocardiographically was comparable to that measured by quantitative histological examination (29 +/- 10 vs 28 +/- 5%; NS). 3. The present study indicates that postinfarction remodelling leading to LV cavity dilation, hypertrophy of surviving myocardium and impaired systolic function is apparent 4 weeks following moderate size MI in the rat. 4. Transthoracic echocardiography is a noninvasive technique that may be used to assess serially the efficacy of therapeutic interventions designed to prevent remodelling in moderate size MI in the rat.en_US
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCoronary Vessels.pathology.physiologyen
dc.subject.otherEchocardiographyen
dc.subject.otherFemaleen
dc.subject.otherHeart Function Testsen
dc.subject.otherHemodynamics.physiologyen
dc.subject.otherMyocardial Infarction.pathology.physiopathologyen
dc.subject.otherMyocardium.pathologyen
dc.subject.otherNeovascularization, Pathologic.pathology.physiopathologyen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.titleValidation of an echocardiographic assessment of cardiac function following moderate size myocardial infarction in the rat.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages570-2en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8800587en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
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