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dc.contributor.authorSeeman, Egoen
dc.contributor.authorHopper, John Len
dc.contributor.authorYoung, N Ren
dc.contributor.authorFormica, Cen
dc.contributor.authorGoss, Pen
dc.contributor.authorTsalamandris, Conen
dc.identifier.citationThe American Journal of Physiology; 270(2 Pt 1): E320-7en
dc.description.abstractAre the associations between muscle strength, lean mass, and bone mineral density (BMD) genetically determined? Based on within-pair differences in 56 monozygotic (MZ) and 56 dizygotic (DZ) female twin pairs, mean age 45 yr (range 24-67), BMD was associated with lean mass, independent of fat mass and height (P < 0.05). A 10% increment in femoral neck (FN) BMD was associated with a 15% increment in lean mass (approximately 6 kg). BMD was associated with muscle strength (measured in 35 pairs) before, but not after, adjusting for lean mass. Based on age-adjusted cross-sectional analyses, same-trait correlations (+/- SE) in MZ pairs were double those in DZ pairs: FN BMD (0.62 +/- 0.08, 0.33 +/- 0.12) and lean mass (0.87 +/- 0.03, 0.30 +/- 0.11; all P < 0.001), consistent with a genetic hypothesis. The cross-trait correlation (r) between lean mass and FN BMD in the same individual was 0.43 +/- 0.06. The cross-trait cross-twin correlation between lean mass in one twin and FN BMD in the other was 0.31 +/- 0.07 in MZ pairs, approximately 75% of the cross-trait correlation (r) and 0.19 +/- 0.09 in DZ paris (P < 0.001). After adjusting for height and fat mass, the MZ and DZ cross-trait cross-twin correlations were no different (0.16 +/- 0.08 and 0.13 +/- 0.09, respectively). Therefore, genetic factors account for 60-80% of the individual variances of both FN BMD and lean mass, and > 50% of their covariance. The association between greater muscle mass and greater BMD is likely to be determined by genes regulating size.en
dc.subject.otherBody Compositionen
dc.subject.otherBody Heighten
dc.subject.otherBone Densityen
dc.subject.otherMiddle Ageden
dc.subject.otherTwins, Dizygotic.geneticsen
dc.subject.otherTwins, Monozygotic.geneticsen
dc.titleDo genetic factors explain associations between muscle strength, lean mass, and bone density? A twin study.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Physiologyen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital and Repatriation Medical Center, Melbourne, Australiaen
dc.type.austinJournal Articleen, Ego
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
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