Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13436
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dc.contributor.authorBaird, A Een
dc.contributor.authorAustin, M Cen
dc.contributor.authorMcKay, W Jen
dc.contributor.authorDonnan, Geoffrey Aen
dc.date.accessioned2015-05-16T03:17:11Z
dc.date.available2015-05-16T03:17:11Z
dc.date.issued1996-07-01en
dc.identifier.citationJournal of Neurology, Neurosurgery, and Psychiatry; 61(1): 26-9en
dc.identifier.govdoc8676153en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13436en
dc.description.abstractOne major therapeutic strategy to minimise the extent of infarction after ischaemic stroke is to improve early reperfusion using thrombolytic agents. However, reperfusion may be hazardous and the period during which reperfusion may have a beneficial effect on tissue and clinical outcome is not known.Fifty three patients were studied with serial cerebral perfusion (99mTcHMPAO SPECT) during the first 48 hours of ischaemic stroke to determine if changes in tissue perfusion during this time were prognostically significant. Single and multiple linear regression non-parametric analyses were used to include other factors during the same period which may influence outcome.In univariate analysis age, neurological score at admission, SPECT perfusion defect size in the first 24 hours, and percentage change in cerebral tissue perfusion at 24-48 hours (all P < 0.01) correlated significantly with the Barthel score at three months. In multiple linear regression analysis only age (P < 0.01) and percentage change in cerebral tissue perfusion at 24-48 hours (P < 0.01) provided independent prognostic information at three months.Changes in cerebral tissue perfusion during the first 48 hours of ischaemic stroke are significant outcome predictors and therapeutic effort aimed at increasing perfusion during this period seem to be justified.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherBrain Ischemia.drug therapy.mortality.radionuclide imagingen
dc.subject.otherCerebral Cortex.blood supply.radionuclide imagingen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHypertensionen
dc.subject.otherInjections, Intra-Arterialen
dc.subject.otherInjections, Intravenousen
dc.subject.otherMaleen
dc.subject.otherPrognosisen
dc.subject.otherProspective Studiesen
dc.subject.otherStatistics, Nonparametricen
dc.subject.otherStreptokinase.therapeutic useen
dc.subject.otherSurvival Rateen
dc.subject.otherTime Factorsen
dc.subject.otherTomography, Emission-Computed, Single-Photonen
dc.subject.otherTreatment Outcomeen
dc.titleChanges in cerebral tissue perfusion during the first 48 hours of ischaemic stroke: relation to clinical outcome.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of neurology, neurosurgery, and psychiatryen
dc.identifier.affiliationDepartment of Neurology, Austin Hospital, (Melbourne), Victoria, Australiaen
dc.description.pages26-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8676153en
dc.type.austinJournal Articleen
local.name.researcherDonnan, Geoffrey A
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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