Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13351
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dc.contributor.authorRubinstein, Cen
dc.contributor.authorFletcher, D Ren
dc.contributor.authorShulkes, Arthuren
dc.date.accessioned2015-05-16T03:11:11Z
dc.date.available2015-05-16T03:11:11Z
dc.date.issued1993-07-08en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 20(7-8): 477-81en
dc.identifier.govdoc8403527en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13351en
dc.description.abstract1. Calcitonin gene-related peptide (CGRP) is a potent vaso-active 37 amino acid peptide, typically elevated in plasma from patients with medullary thyroid cancer (MTC), but undetectable in the plasma of normal subjects. 2. The kidney is a major site for the clearance of exogenously infused CGRP but the intrarenal site of this clearance is unknown. Extra-organ clearance is also significant for CGRP, and whereas the site and mechanism of this degradation remain uncertain, the vasculature has been postulated as the most likely site. 3. The isolated perfused rat kidney (IPRK) was studied to (i) localize the intrarenal site of CGRP clearance and (ii) determine the contribution of the renal vasculature to the clearance of CGRP. The half-life of CGRP in the filtering IPRK was 63.9 +/- 4.5 min, whereas blocking of filtration by elevation of the perfusate osmolarity abolished the degradation. This suggests that (i) renal CGRP degradation occurs after glomerular filtration with intratubular metabolism and (ii) that there is no active CGRP degradation in the (glomerular) capillary endothelium. 4. These results do not support the theory that renal vascular endothelium plays a major active role in CGRP degradation.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCalcitonin Gene-Related Peptide.metabolismen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherHalf-Lifeen
dc.subject.otherKidney.metabolismen
dc.subject.otherOsmolar Concentrationen
dc.subject.otherPerfusionen
dc.subject.otherRatsen
dc.titleThe intrarenal site of calcitonin gene-related peptide degradation in the isolated perfused rat kidney.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages477-81en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8403527en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
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