Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13335
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dc.contributor.authorFitt, Gregory Jen
dc.contributor.authorFarrar, Jen
dc.contributor.authorBaird, A Een
dc.contributor.authorBrooks, Duncan Marken
dc.contributor.authorGilligan, Aen
dc.contributor.authorDonnan, Geoffrey Aen
dc.contributor.authorHennessy, O Fen
dc.date.accessioned2015-05-16T03:10:03Z
dc.date.available2015-05-16T03:10:03Z
dc.date.issued1993-09-06en
dc.identifier.citationMedical Journal of Australia; 159(5): 331-4en
dc.identifier.govdoc8361430en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13335en
dc.description.abstractTo assess the safety and efficacy of the intra-arterial administration of streptokinase within 24 hours of acute ischaemic stroke.Patients who presented to the Austin Hospital casualty department between 3 and 22 hours after an acute stroke were considered for the study. Eligible patients had pretreatment non-contrast computed tomographic scans of the brain to exclude haemorrhage. Streptokinase (250,000 units) was administered directly into the common carotid artery or the cervical portion of the internal carotid artery.The incidence of symptomatic and asymptomatic cerebral haemorrhage, haemorrhagic transformation of infarction, angiographic reperfusion, clinical outcome at seven to 10 days and the frequency of other complications.Thirteen patients were treated over a 16-month period. Major clinical improvement occurred in five patients (39%) at 48 hours. This was associated with angiographically demonstrated recanalisation of a middle cerebral artery occlusion in two patients and partial recanalisation in two others. Significant hypotension in two patients required therapy to be stopped. In five other cases mild hypotension developed but the streptokinase infusion was completed. Haemorrhagic transformation of the infarct occurred in four patients without clinical deterioration.Intra-arterial administration of streptokinase is safe in selected patients with acute ischaemic stroke. The theoretical benefit of an increased local thrombolytic effect and reduced systemic complications, compared with the use of higher intravenous doses, justifies a randomised clinical trial. If therapies such as this are to be successful, rapid referral to an appropriate centre is necessary.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAngiography, Digital Subtractionen
dc.subject.otherBrain Ischemia.drug therapy.radiographyen
dc.subject.otherCarotid Artery, Common.radiographyen
dc.subject.otherCarotid Artery, Internal.radiographyen
dc.subject.otherCarotid Stenosis.drug therapy.radiographyen
dc.subject.otherCatheterizationen
dc.subject.otherCerebral Arterial Diseases.drug therapy.radiographyen
dc.subject.otherCerebrovascular Disorders.drug therapy.radiographyen
dc.subject.otherConstriction, Pathologic.drug therapy.radiographyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHypotension.chemically induceden
dc.subject.otherInfusions, Intra-Arterialen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPilot Projectsen
dc.subject.otherStreptokinase.administration & dosage.adverse effects.therapeutic useen
dc.subject.otherThrombolytic Therapyen
dc.subject.otherTomography, X-Ray Computeden
dc.titleIntra-arterial streptokinase in acute ischaemic stroke. A pilot study.en
dc.typeJournal Articleen
dc.identifier.journaltitleMedical Journal of Australiaen
dc.identifier.affiliationDepartment of Radiology, Austin Hospital, Heidelberg, Vic.en
dc.description.pages331-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8361430en
dc.type.austinJournal Articleen
local.name.researcherBrooks, Duncan Mark
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRadiology-
crisitem.author.deptRadiology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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