Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13264
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTsalamandris, Conen
dc.contributor.authorAllen, Terri Jen
dc.contributor.authorGilbert, Richard Een
dc.contributor.authorSinha, Aen
dc.contributor.authorPanagiotopoulos, Siannaen
dc.contributor.authorCooper, Mark Een
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-16T03:05:08Z-
dc.date.available2015-05-16T03:05:08Z-
dc.date.issued1994-05-01en
dc.identifier.citationDiabetes; 43(5): 649-55en
dc.identifier.govdoc8168641en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13264en
dc.description.abstractThis study describes patterns of progression of albuminuria and renal function in a subgroup of 40 patients from a total cohort of 211 diabetic patients (118 type I, 93 type II) followed over a period of 8-14 years. Forty patients (18 with type I diabetes, 22 with type II diabetes) showed progressive increases in albumin excretion rate (AER) and/or decreases in creatinine clearance (CC) during the study period. Of these, AER alone increased in 15 patients, AER increased and CC decreased in 13 patients, and CC alone decreased in 12 patients, with a similar distribution of type I and type II diabetic patients in each group. Of the 28 patients who showed an increase in albuminuria, AER increased at an annual rate of 30-40%, resulting in a 4- to 8-fold increase in AER to > 20 micrograms/min during the study. Of the 25 patients who showed a decrease in renal function, CC decreased at an annual rate of 4-5 ml/min, resulting in an approximate halving of CC to < 90 ml/min during the study. The rate of fall in CC was not related to the presence or absence of concomitant increases in albuminuria. However, a significant preponderance of women in the group showed a decline in CC alone. The decline in CC was associated with an increase in plasma creatinine as well as a progressive decrease in urinary creatinine excretion, but the underlying mechanisms remain unexplained. These data support the concept that a subgroup of diabetic patients may show a decline in renal function in the absence of significant increases in AER.(ABSTRACT TRUNCATED AT 250 WORDS)en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAlbuminuriaen
dc.subject.otherBlood Pressureen
dc.subject.otherBody Weighten
dc.subject.otherCreatinine.metabolismen
dc.subject.otherDiabetes Mellitus, Type 1.blood.physiopathology.urineen
dc.subject.otherDiabetes Mellitus, Type 2.blood.physiopathology.urineen
dc.subject.otherDiabetic Nephropathies.blood.physiopathology.urineen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherHumansen
dc.subject.otherHypertension.physiopathologyen
dc.subject.otherKidney.physiopathologyen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherSex Factorsen
dc.subject.otherTime Factorsen
dc.titleProgressive decline in renal function in diabetic patients with and without albuminuria.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetesen
dc.identifier.affiliationEndocrine Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages649-55en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8168641en
dc.identifier.orcid0000-0002-0845-0001-
dc.type.austinJournal Articleen
local.name.researcherJerums, George
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptOffice for Research-
crisitem.author.deptEndocrinology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

14
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.