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dc.contributor.authorGrant, Sharon Len
dc.contributor.authorPhillips, P Aen
dc.contributor.authorGow, Paul Jen
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 21(3): 243-7en
dc.description.abstract1. Epidermal growth factor is a potent mitogen that causes natriuresis, diuresis and inhibition of arginine vasopressin-induced water reabsorption. 2. The aim of this study was to determine any interaction between epidermal growth factor and the V1 (vascular) and/or V2 (antidiuretic) arginine vasopressin receptor subtypes. 3. Radioligand binding displacement assays demonstrated that although arginine vasopressin related peptides displaced both radioligands from renal medullary membranes at low concentrations epidermal growth factor displaced neither. 4. Arginine vasopressin V2 receptor second messenger cyclic adenosine monophosphate (cAMP) production was inhibited by epidermal growth factor (IC50 2 x 10(-7) mol/L) as was sodium fluoride cAMP production but only at much higher concentrations. 5. Therefore the diuretic effect of epidermal growth factor is not via direct antagonism of arginine vasopressin receptors but seems mediated via inhibition of the V2 second messenger system.en
dc.subject.otherAdenylate Cyclase.metabolism.physiologyen
dc.subject.otherAngiotensin II.pharmacologyen
dc.subject.otherArginine Vasopressin.antagonists & inhibitors.metabolism.pharmacologyen
dc.subject.otherBinding, Competitiveen
dc.subject.otherCyclic AMP.biosynthesisen
dc.subject.otherDrug Interactionsen
dc.subject.otherEpidermal Growth Factor.physiologyen
dc.subject.otherKidney Medulla.drug effects.metabolism.physiologyen
dc.subject.otherMembranes.drug effects.metabolismen
dc.subject.otherRadioligand Assayen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherReceptors, Vasopressin.metabolism.physiologyen
dc.subject.otherSecond Messenger Systems.drug effects.physiologyen
dc.titleInteraction between epidermal growth factor and arginine vasopressin in renal medullary membranes.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Victoria, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Liver Transplant Unit- and Hepatology-
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