Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13153
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dc.contributor.authorStraznicky, N Een
dc.contributor.authorHowes, L Gen
dc.contributor.authorLam, Wen
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T02:56:30Z
dc.date.available2015-05-16T02:56:30Z
dc.date.issued1995-03-15en
dc.identifier.citationThe American Journal of Cardiology; 75(8): 582-6en
dc.identifier.govdoc7887382en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13153en
dc.description.abstractThis study was conducted to examine the effects of short-term cholesterol reduction on cardiovascular reactivity in mildly hypertensive patients. Seven male and 7 female patients, aged 34 to 68 years, received pravastatin (40 mg/day) or matched placebo for 3 weeks in a randomized, double-blind, crossover study. Cardiovascular reactivity was assessed by measurement of blood pressure (BP) responses to incremental infusions of angiotensin II and norepinephrine, by cold pressor testing and isometric exercise. Compared with placebo, pravastatin caused significant reductions in plasma total and low-density lipoprotein cholesterol levels, which averaged 20% and 31%, respectively (both p < 0.0001), and in diastolic BP responses (expressed as the infusion rate required to raise BP by 20 mm Hg) to both angiotensin II (7.3 +/- 3.0 vs 9.7 +/- 4.7 ng/kg/min, p = 0.05) and norepinephrine (0.15 +/- 0.13 vs 0.38 +/- 0.33 micrograms/kg/min, p = 0.03). Systolic BP responses were similar with both treatments. Body weight, resting BP, and maximal BP responses to physical stressors were similar with each treatment.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAngiotensin II.drug effectsen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherCardiovascular System.drug effects.physiopathologyen
dc.subject.otherCholesterol.blooden
dc.subject.otherCross-Over Studiesen
dc.subject.otherDouble-Blind Methoden
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHypercholesterolemia.complications.drug therapy.physiopathologyen
dc.subject.otherHypertension.complications.physiopathologyen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNorepinephrine.antagonists & inhibitorsen
dc.subject.otherPravastatin.pharmacology.therapeutic useen
dc.subject.otherTreatment Outcomeen
dc.titleEffects of pravastatin on cardiovascular reactivity to norepinephrine and angiotensin II in patients with hypercholesterolemia and systemic hypertension.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe American journal of cardiologyen
dc.identifier.affiliationDepartment of Clinical Pharmacology and Therapeutics, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages582-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7887382en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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