Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13149
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dc.contributor.authorO'Callaghan, Christopher Jen
dc.contributor.authorKrum, Henryen
dc.contributor.authorConway, Elizabeth Len
dc.contributor.authorLam, Wen
dc.contributor.authorSkiba, M Aen
dc.contributor.authorHowes, L Gen
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T02:56:14Z
dc.date.available2015-05-16T02:56:14Z
dc.date.issued1995-02-20en
dc.identifier.citationMedical Journal of Australia; 162(4): 206-8en
dc.identifier.govdoc7877544en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13149en
dc.description.abstractTo determine the efficacy of pravastatin in the treatment of primary hypercholesterolaemia in patients being treated with captopril for hypertension.A double-blind parallel group study comparing 12 weeks of pravastatin therapy (20-40 mg/day) with placebo.25 patients (age, 37-73 years) with mild-to-moderate hypertension and hypercholesterolaemia (total cholesterol level, 5.5-8.8 mmol/L).Pravastatin reduced total cholesterol levels by 22% (from 7.1 +/- 0.29 [SEM] to 5.5 +/- 0.25 mmol/L; P < 0.001) and low-density-lipoprotein cholesterol levels by 32% (from 5.0 +/- 0.32 to 3.4 +/- 0.28 mmol/L; P < 0.001) in four weeks and these levels were maintained for the 12 weeks of therapy. Pre-pravastatin values returned three weeks after stopping therapy. Levels of total cholesterol, cholesterol fractions and triglycerides remained constant or deteriorated in the placebo group. Pravastatin therapy was well tolerated. An integrated coronary risk score showed a 40% reduction in risk.This study indicates that pravastatin (combined with captopril) is an effective cholesterol-lowering drug, but that treatment needs to be maintained.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAnalysis of Varianceen
dc.subject.otherCaptopril.therapeutic useen
dc.subject.otherCholesterol.blooden
dc.subject.otherDouble-Blind Methoden
dc.subject.otherDrug Therapy, Combinationen
dc.subject.otherHumansen
dc.subject.otherHypercholesterolemia.blood.complications.drug therapyen
dc.subject.otherHypertension.blood.complications.drug therapyen
dc.subject.otherMiddle Ageden
dc.subject.otherPravastatin.therapeutic useen
dc.subject.otherTreatment Outcomeen
dc.titleEfficacy of pravastatin in combination with captopril in hypertensive patients.en
dc.typeJournal Articleen
dc.identifier.journaltitleMedical Journal of Australiaen
dc.identifier.affiliationHypertension Services, Austin Hospital, Melbourne, VIC.en
dc.description.pages206-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7877544en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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