Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13140
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dc.contributor.authorMacGregor, Duncanen
dc.contributor.authorMurone, Carmelen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T02:55:38Z
dc.date.available2015-05-16T02:55:38Z
dc.date.issued1994-11-01en
dc.identifier.citationNeurochemistry International; 25(5): 413-7en
dc.identifier.govdoc7849569en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13140en
dc.description.abstractQuantitative in vitro autoradiography was used to assess the post mortem stability of angiotensin II receptors and angiotensin converting enzyme in adult sheep brainstems. There was no significant loss of angiotensin II receptor binding in brainstems stored for up to 24 h at 23 degrees C or for 8 h at 23 degrees C followed by 64 h at 4 degrees C. There was no significant decrease in angiotensin converting enzyme binding in the same nuclei after up to 48 h at 23 degrees C or after 8 h at 23 degrees C followed by up to 64 h at 4 degrees C. Interpretation of neurochemical studies of human brain tissue obtained at autopsy requires assessment of the post mortem stability of the molecules being studied. Our results indicate that angiotensin II receptors and angiotensin converting enzyme are remarkably stable in sheep brainstems after post mortem delays in excess of those usually encountered in hospital autopsies.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherBrain Stem.chemistryen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherPeptidyl-Dipeptidase A.analysisen
dc.subject.otherPostmortem Changesen
dc.subject.otherReceptors, Angiotensin.analysisen
dc.subject.otherSheepen
dc.titleThe stability of angiotensin receptors and angiotensin converting enzyme in post mortem brain.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurochemistry internationalen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria.en
dc.description.pages413-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7849569en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
Appears in Collections:Journal articles
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