Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13082
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dc.contributor.authorSandrin, Mauro Sen
dc.contributor.authorMouhtouris, Een
dc.contributor.authorVaughan, Hilary Aen
dc.contributor.authorWarren, H Sen
dc.contributor.authorParish, C Ren
dc.date.accessioned2015-05-16T02:51:45Z
dc.date.available2015-05-16T02:51:45Z
dc.date.issued1993-11-01en
dc.identifier.citationJournal of Immunology (baltimore, Md. : 1950); 151(9): 4606-13en
dc.identifier.govdoc7691954en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13082en
dc.description.abstractCOS cells transiently transfected with human CD48 were found to bind human PBL, whereas mock or CD7-transfected COS cells failed to bind human lymphocytes. Binding of PBL to CD48 transfectants was almost totally inhibited by either CD48 mAb pretreatment of COS cells or CD2 mAb pretreatment of PBL, implying an interaction between CD2 and CD48. This conclusion was confirmed by the demonstration that a highly fluorescent, multimeric form of rCD2 bound to CD48 transfected COS cells in a CD48-dependent manner. Additional mAb blocking studies revealed that CD48 interacts with the T11(1) region of CD2, the same region of CD2 that binds LFA-3 (CD58). Thus, CD48 and CD58 represent alternative and possibly competing ligands for CD2, although based on blocking studies with soluble CD2, CD48 interacts with CD2 with approximately a 100-fold lower affinity that CD58.en
dc.language.isoenen
dc.subject.otherAntibodies, Monoclonal.immunologyen
dc.subject.otherAntigens, CD.analysis.metabolismen
dc.subject.otherAntigens, CD2en
dc.subject.otherAntigens, Differentiation, T-Lymphocyte.metabolismen
dc.subject.otherCell Adhesionen
dc.subject.otherCell Lineen
dc.subject.otherEpitopesen
dc.subject.otherHumansen
dc.subject.otherLigandsen
dc.subject.otherLymphocytes.immunology.metabolismen
dc.subject.otherReceptors, Immunologic.metabolismen
dc.subject.otherRecombinant Proteins.metabolismen
dc.subject.otherTransfectionen
dc.titleCD48 is a low affinity ligand for human CD2.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Immunology (Baltimore, Md. : 1950)en
dc.identifier.affiliationMolecular Immunogenetics Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages4606-13en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7691954en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptInfectious Diseases-
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