Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13074
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dc.contributor.authorLam, Wen
dc.contributor.authorLouis, William Jen
dc.contributor.authorVerberne, Anthony J Men
dc.date.accessioned2015-05-16T02:51:13Z
dc.date.available2015-05-16T02:51:13Z
dc.date.issued1995-05-17en
dc.identifier.citationJournal of the Autonomic Nervous System; 53(1): 35-42en
dc.identifier.govdoc7673600en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13074en
dc.description.abstractCertain areas within the periaqueductal grey (PAG) have been implicated in cardiovascular regulation. The influence of excitotoxic lesions of the caudal dorsal periaqueductal grey on the baroreceptor-heart rate reflex and the cardiovascular response to air-jet stress was examined in awake Wistar-Kyoto rats. Pressor (11 +/- 2 mmHg) and tachycardic (25 +/- 4 beats/min) responses to air-jet were not influenced by the lesion. Similarly, the resting MAP and HR were unchanged. However, the gain of the baroreflex was reduced from -3.9 +/- 0.1 to -2.8 +/- 0.3 beats/min per mmHg and the upper threshold was increased from 120 +/- 5 to 135 +/- 7 mmHg in the lesioned group. These observations suggest that although the caudal dorsal PAG does not appear to exert a tonic influence on vasomotor tone or mediate the air-jet response, it may provide a facilitatory input to the baroreceptor-heart rate reflex.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBaroreflex.physiologyen
dc.subject.otherBlood Pressure.physiologyen
dc.subject.otherHeart Rate.physiologyen
dc.subject.otherHemodynamics.physiologyen
dc.subject.otherMaleen
dc.subject.otherN-Methylaspartate.toxicityen
dc.subject.otherPeriaqueductal Gray.anatomy & histology.physiologyen
dc.subject.otherPhysical Stimulationen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherStereotaxic Techniquesen
dc.subject.otherStress, Physiological.physiopathologyen
dc.titleEffect of dorsal periaqueductal grey lesion on baroreflex and cardiovascular response to air-jet stress.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of the autonomic nervous systemen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages35-42en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7673600en
dc.type.austinJournal Articleen
local.name.researcherLouis, William J
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMedicine (University of Melbourne)-
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