Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13065
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dc.contributor.authorBach, Leon Aen
dc.contributor.authorCooper, Mark Een
dc.contributor.authorVranes, Den
dc.contributor.authorAllen, Terri Jen
dc.contributor.authorRumble, J Ren
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-16T02:50:37Z
dc.date.available2015-05-16T02:50:37Z
dc.date.issued1994-05-16en
dc.identifier.citationDiabetes Research (edinburgh, Scotland); 27(1): 27-38en
dc.identifier.govdoc7648794en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13065en
dc.description.abstractDiabetic children are protected from the complications of diabetes until puberty, suggesting the involvement of a hormonal mechanism. In order to investigate the contribution of sex steroids to the development of diabetic nephropathy, castrated Wistar-Kyoto rats were made diabetic with streptozotocin and compared with intact diabetic rats. In intact rats, 32 weeks of diabetes resulted in hyperfiltration (p = 0.0001) and a marked increase in albuminuria (control, 1.3 x/divided by 1.3 vs diabetes intact, 11.8 x/divided by 1.3 mg/day, p < 0.001). Concomitant structural changes included glomerular basement membrane thickening (diabetes, 199.2 +/- 7.9 vs control, 175.9 +/- 3.9 nm, p = 0.02) and increased mesangial volume (diabetes, 194 +/- 14 vs control, 129 +/- 20 microns 3, p = 0.02). Although castration resulted in blood pressure lowering of 12 mmHg (p = 0.0003), albuminuria increased to the same extent in intact and castrated diabetic rats (castrated diabetic 10.5 x/divided by 1.3 mg/day). Glomerular filtration rate was lower in castrated rats than in intact rats prior to induction of diabetes, but increased similarly with induction of diabetes. Castrated diabetic rats had increased mesangial volume (castrated diabetic, 213 +/- 20 microns 3), but glomerular basement membrane thickness was lower than in intact diabetic rats (castrated diabetic, 179.5 +/- 4.5 nm). Thus, there is a dissociation between basement membrane thickening and albuminuria in this model of diabetic kidney disease. The mechanism of action of castration on glomerular function and structure remains to be elucidated but may relate to indirect effects such as reduction of blood pressure or renal polyol accumulation or a direct effect of sex steroids.en
dc.language.isoenen
dc.subject.otherAlbuminuriaen
dc.subject.otherAnimalsen
dc.subject.otherBasement Membrane.pathologyen
dc.subject.otherBlood Glucose.metabolismen
dc.subject.otherBlood Pressureen
dc.subject.otherBody Weighten
dc.subject.otherDiabetes Mellitus, Experimental.pathology.physiopathologyen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherGlomerular Mesangium.cytology.pathologyen
dc.subject.otherKidney.pathology.physiology.physiopathologyen
dc.subject.otherKidney Glomerulus.pathologyen
dc.subject.otherMaleen
dc.subject.otherOrchiectomyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherReference Valuesen
dc.subject.otherTime Factorsen
dc.titleDisparate effects of castration on renal structure and function in the streptozotocin diabetic rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetes research (Edinburgh, Scotland)en
dc.identifier.affiliationEndocrine Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages27-38en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7648794en
dc.type.austinJournal Articleen
local.name.researcherJerums, George
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptEndocrinology-
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