Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13063
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dc.contributor.authorReutens, David Cen
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T02:50:29Z
dc.date.available2015-05-16T02:50:29Z
dc.date.issued1995-08-01en
dc.identifier.citationNeurology; 45(8): 1469-76en
dc.identifier.govdoc7644043en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13063en
dc.description.abstractJuvenile myoclonic epilepsy, juvenile absence epilepsy, and epilepsy with generalized tonic-clonic seizures (GTCS) on awakening are the three syndromes of idiopathic generalized epilepsy of adolescent onset currently included in the classification of epilepsy syndromes of the International League Against Epilepsy (ILAE). Although they differ in their predominant seizure types, the syndromes share several clinical features, thus giving rise to questions of phenotypic overlap and purity. We studied the clinical features of 101 patients with idiopathic generalized epilepsy beginning in adolescence. A standardized interview was used to elucidate seizure phenomenology, precipitants, frequency, and response to treatment. Groups defined by seizure type were compared and their similarities examined. The group with myoclonic but not absence seizures (21 patients) corresponded to the ILAE syndrome of juvenile myoclonic epilepsy, whereas those with absences but not myoclonus (37 patients) resembled juvenile absence epilepsy. Twenty-six patients shared the features of juvenile myoclonic epilepsy and juvenile absence epilepsy. Epilepsy with GTCS on awakening was not a specific syndromic entity; 10 patients had this seizure type alone. Seven patients were without a syndromic diagnosis. In these patients only GTCS occurred, but neither on awakening nor in the evening period of relaxation. We conclude that whilst syndromes of idiopathic generalized epilepsy of adolescence can be recognized, the current classification does not include all patients. In addition, the boundaries between the syndromes are indistinct, suggesting underlying neurobiological, possibly genetic, relationships.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherAge of Onseten
dc.subject.otherChilden
dc.subject.otherEpilepsies, Myoclonic.classification.complicationsen
dc.subject.otherEpilepsy.classificationen
dc.subject.otherEpilepsy, Absence.classification.complicationsen
dc.subject.otherEpilepsy, Generalized.diagnosis.physiopathology.therapyen
dc.subject.otherEpilepsy, Tonic-Clonic.classificationen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherInterviews as Topicen
dc.subject.otherMaleen
dc.subject.otherSyndromeen
dc.titleIdiopathic generalized epilepsy of adolescence: are the syndromes clinically distinct?en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationDepartment of Neurology, Austin Hospital, Heidelberg (Melbourne), Victoria, Australiaen
dc.description.pages1469-76en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7644043en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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