Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12996
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dc.contributor.authorDonnan, Geoffrey Aen
dc.contributor.authorKaczmarczyk, S Jen
dc.contributor.authorMcKenzie, J Sen
dc.contributor.authorRowe, P Jen
dc.contributor.authorKalnins, Renate Men
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T02:46:01Z
dc.date.available2015-05-16T02:46:01Z
dc.date.issued1987-11-01en
dc.identifier.citationJournal of the Neurological Sciences; 81(2-3): 261-71en
dc.identifier.govdoc3501002en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12996en
dc.description.abstractWhen the regional effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on brain dopamine uptake sites in C57 Black mice were studied using [3H]mazindol autoradiography, marked regional differences in effect were seen: the mesolimbic system was less affected than the nigrostriatal tract and within each system the effect was more severe in the terminal fields of the striatum than in the cells of origin. Within the striatum itself there was inhomogeneity of effect, with relative sparing of the dorsomedial aspect compared to the remainder. Complete recovery of [3H]mazindol binding to striatal membranes occurred over 12 months, while dopamine levels recovered more slowly. This supports the concept that MPTP has a highly selective effect within dopaminergic systems and that the initial effect is more pronounced on distal terminals compared to cell bodies. The possibility that recovery of mazindol binding with time may be associated with terminal regrowth needs to be investigated further.en
dc.language.isoenen
dc.subject.other1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherBrain.drug effects.metabolismen
dc.subject.otherDopamine.metabolismen
dc.subject.otherInjections, Intraperitonealen
dc.subject.otherMazindol.metabolismen
dc.subject.otherMiceen
dc.subject.otherMice, Inbred C57BLen
dc.subject.otherPyridines.administration & dosage.pharmacologyen
dc.subject.otherReceptors, Dopamine.drug effects.metabolismen
dc.subject.otherTime Factorsen
dc.titleRegional and temporal effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on dopamine uptake sites in mouse brain.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of the neurological sciencesen
dc.identifier.affiliationDepartment of Neurology, Austin Hospital, University of Melbourne, Australiaen
dc.description.pages261-71en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3501002en
dc.type.austinJournal Articleen
local.name.researcherDonnan, Geoffrey A
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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