Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12967
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dc.contributor.authorJerums, Georgeen
dc.contributor.authorCooper, Mark Een
dc.contributor.authorSeeman, Egoen
dc.contributor.authorMurray, R Men
dc.contributor.authorMcNeil, John Jen
dc.date.accessioned2015-05-16T02:44:04Z
dc.date.available2015-05-16T02:44:04Z
dc.date.issued1988-01-07en
dc.identifier.citationDiabetes Research and Clinical Practice; 4(2): 133-41en
dc.identifier.govdoc3342732en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12967en
dc.description.abstractThis study has investigated the relationship of glycaemic control, blood pressure and proteinuria to early renal dysfunction in a cohort of 50 type I and 65 type II diabetics, with renal function ranging from normal to mildly impaired (serum creatinine less than 0.2 mM). Repeated measurements were made over a mean interval of 7 years and mean data from each subject were analysed by stepwise multiple linear regression. This enabled associations to be determined independently of the confounding influence of age and duration of disease. In type I diabetics, mean creatinine clearance was inversely related to systolic blood pressure (P less than 0.001), glycosylated haemoglobin (P less than 0.05), fasting plasma glucose (P less than 0.05) and to the renal clearance of albumin (P less than 0.001), transferrin (P less than 0.01) and IgG (P less than 0.05). By contrast, in type II diabetics, none of these associations were significant. No significant relationships were found with the rate of decline of creatinine clearance in either type of diabetic. Further studies will be needed to determine whether the changes in blood pressure and glycaemic control precede or follow the development of renal disease. However, these findings raise the possibility of a difference in the pathogenesis of renal disease in type I and type II diabetes.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherDiabetes Mellitus, Type 1.complications.urineen
dc.subject.otherDiabetes Mellitus, Type 2.complications.urineen
dc.subject.otherDiabetic Nephropathies.etiology.urineen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHyperglycemia.urineen
dc.subject.otherHypertension.urineen
dc.subject.otherKidney Failure, Chronic.etiology.urineen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.titleComparison of early renal dysfunction in type I and type II diabetes: differing associations with blood pressure and glycaemic control.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetes research and clinical practiceen
dc.identifier.affiliationUniversity of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages133-41en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3342732en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
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