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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12915
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dc.contributor.authorJackson, B-
dc.contributor.authorFranze, L-
dc.contributor.authorAllen, Terri J-
dc.contributor.authorO'Brien, R-
dc.contributor.authorCooper, Mark E-
dc.contributor.authorHodsman, G P-
dc.contributor.authorJerums, George-
dc.date.accessioned2015-05-16T02:40:32Z
dc.date.available2015-05-16T02:40:32Z
dc.date.issued1988-04-01-
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 15(4): 361-5en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12915en
dc.description.abstract1. Diabetes was induced in 32 adult Wistar-Kyoto rats with streptozotocin (60 mg/kg). Fourteen rats remained untreated, 10 received insulin three times per week, and eight received insulin daily. Fourteen non-diabetic rats served as controls. 2. Exchangeable sodium and plasma volume were elevated in the untreated diabetic rats. Treatment normalized these parameters. 3. Glomerular filtration rate (GFR) was elevated in the untreated diabetic group and the group receiving insulin three times per week compared with the control group. Daily insulin treatment restored GFR towards control values. 4. Plasma atrial natriuretic factor was similar in untreated diabetic rats and non-diabetic rats.en_US
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAtrial Natriuretic Factor.blooden
dc.subject.otherBlood Glucose.metabolismen
dc.subject.otherBlood Volume.drug effectsen
dc.subject.otherBody Weight.drug effectsen
dc.subject.otherDiabetes Mellitus, Experimental.blood.drug therapy.physiopathologyen
dc.subject.otherGlomerular Filtration Rate.drug effectsen
dc.subject.otherInsulin.therapeutic useen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherSodium.metabolismen
dc.titleEffect of glycaemic control on glomerular filtration rate in the streptozotocin diabetic rat.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen_US
dc.identifier.affiliationMedicine (University of Melbourne)en_US
dc.description.pages361-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2978746en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherJackson, Belinda D
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptEndocrinology-
crisitem.author.deptUniversity of Melbourne Clinical School-
crisitem.author.deptEndocrinology-
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