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https://ahro.austin.org.au/austinjspui/handle/1/12910
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cooper, Mark E | en |
dc.contributor.author | Frauman, Albert G | en |
dc.contributor.author | O'Brien, R C | en |
dc.contributor.author | Seeman, Ego | en |
dc.contributor.author | Murray, R M | en |
dc.contributor.author | Jerums, George | en |
dc.date.accessioned | 2015-05-16T02:39:46Z | |
dc.date.available | 2015-05-16T02:39:46Z | |
dc.date.issued | 1988-05-06 | en |
dc.identifier.citation | Diabetic Medicine : A Journal of the British Diabetic Association; 5(4): 361-8 | en |
dc.identifier.govdoc | 2968887 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/12910 | en |
dc.description.abstract | A longitudinal study evaluating the time course of the transition from normal to microalbuminuria, and then on to macroalbuminuria, was made over a mean period of 7 years in a cohort of 52 patients with Type 1 diabetes and 61 patients with Type 2 diabetes. Transient episodes of micro- and macroalbuminuria were often observed before the ultimate development of persistent Albustix-positive proteinuria. The transition from normal to microalbuminuria and from micro- to macroalbuminuria was characterized by rises in renal albumin clearance accompanied by lesser rises in total proteinuria. Seven patients with Type 1 and 12 with Type 2 diabetes showed evidence of progression, the interval for the transition from normal to macroalbuminuria varying from 3 to 5 years. In Type 1 diabetic patients, the development of micro- and macroalbuminuria was associated with a decline in renal function and a rise in systolic blood pressure without a significant change in blood glucose control. In Type 2 diabetic patients, the development of microalbuminuria was associated with a small decline in renal function but no change in blood pressure or blood glucose control. It is concluded that the transition from normal to micro- and on to macroalbuminuria may be more rapid then previously reported and varies considerably among individuals. | en |
dc.language.iso | en | en |
dc.subject.other | Adult | en |
dc.subject.other | Albuminuria | en |
dc.subject.other | Blood Glucose.analysis | en |
dc.subject.other | Blood Pressure | en |
dc.subject.other | Creatinine.metabolism | en |
dc.subject.other | Diabetes Mellitus, Type 1.physiopathology.urine | en |
dc.subject.other | Diabetes Mellitus, Type 2.physiopathology.urine | en |
dc.subject.other | Diabetic Retinopathy.urine | en |
dc.subject.other | Female | en |
dc.subject.other | Follow-Up Studies | en |
dc.subject.other | Hemoglobin A, Glycosylated.analysis | en |
dc.subject.other | Humans | en |
dc.subject.other | Male | en |
dc.subject.other | Proteinuria | en |
dc.title | Progression of proteinuria in type 1 and type 2 diabetes. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Diabetic medicine : a journal of the British Diabetic Association | en |
dc.identifier.affiliation | Endocrine Unit, Austin Hospital, University of Melbourne, Australia | en |
dc.description.pages | 361-8 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/2968887 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Frauman, Albert G | |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Clinical Pharmacology and Therapeutics | - |
crisitem.author.dept | Endocrinology | - |
crisitem.author.dept | Endocrinology | - |
Appears in Collections: | Journal articles |
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