Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12910
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dc.contributor.authorCooper, Mark Een
dc.contributor.authorFrauman, Albert Gen
dc.contributor.authorO'Brien, R Cen
dc.contributor.authorSeeman, Egoen
dc.contributor.authorMurray, R Men
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-16T02:39:46Z
dc.date.available2015-05-16T02:39:46Z
dc.date.issued1988-05-06en
dc.identifier.citationDiabetic Medicine : A Journal of the British Diabetic Association; 5(4): 361-8en
dc.identifier.govdoc2968887en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12910en
dc.description.abstractA longitudinal study evaluating the time course of the transition from normal to microalbuminuria, and then on to macroalbuminuria, was made over a mean period of 7 years in a cohort of 52 patients with Type 1 diabetes and 61 patients with Type 2 diabetes. Transient episodes of micro- and macroalbuminuria were often observed before the ultimate development of persistent Albustix-positive proteinuria. The transition from normal to microalbuminuria and from micro- to macroalbuminuria was characterized by rises in renal albumin clearance accompanied by lesser rises in total proteinuria. Seven patients with Type 1 and 12 with Type 2 diabetes showed evidence of progression, the interval for the transition from normal to macroalbuminuria varying from 3 to 5 years. In Type 1 diabetic patients, the development of micro- and macroalbuminuria was associated with a decline in renal function and a rise in systolic blood pressure without a significant change in blood glucose control. In Type 2 diabetic patients, the development of microalbuminuria was associated with a small decline in renal function but no change in blood pressure or blood glucose control. It is concluded that the transition from normal to micro- and on to macroalbuminuria may be more rapid then previously reported and varies considerably among individuals.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAlbuminuriaen
dc.subject.otherBlood Glucose.analysisen
dc.subject.otherBlood Pressureen
dc.subject.otherCreatinine.metabolismen
dc.subject.otherDiabetes Mellitus, Type 1.physiopathology.urineen
dc.subject.otherDiabetes Mellitus, Type 2.physiopathology.urineen
dc.subject.otherDiabetic Retinopathy.urineen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherHemoglobin A, Glycosylated.analysisen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherProteinuriaen
dc.titleProgression of proteinuria in type 1 and type 2 diabetes.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetic medicine : a journal of the British Diabetic Associationen
dc.identifier.affiliationEndocrine Unit, Austin Hospital, University of Melbourne, Australiaen
dc.description.pages361-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2968887en
dc.type.austinJournal Articleen
local.name.researcherFrauman, Albert G
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
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