Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12907
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dc.contributor.authorDrummer, Olaf Hen
dc.contributor.authorKourtis, Sen
dc.date.accessioned2015-05-16T02:39:34Z
dc.date.available2015-05-16T02:39:34Z
dc.date.issued1987-11-01en
dc.identifier.citationArzneimittel-forschung; 37(11): 1225-8en
dc.identifier.govdoc2964241en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12907en
dc.description.abstractThe biotransformation of di-acid inhibitors of angiotensin converting enzyme was studied in the urine of rats using gas chromatography/mass spectrometry. It was found that after oral administration (10 mg/kg) of enalapril significant amounts (9.2%) of a hydrolytic metabolite of enalaprilat were excreted in urine which was identified as 2-N-alanyl-4-phenylbutanoic acid. This metabolite was present only in trace concentrations in urine after intravenous administration. This pathway was not present, however, with either ramipril or perindopril suggesting that the amide bond in these newer inhibitors is more resistant to hydrolysis than for enalapril. Glucuronidase hydrolysis of urine obtained from rats dosed with either enalapril, ramipril or perindopril indicated the absence of glucuronidate conjugates of these inhibitors in rat urine.en
dc.language.isoenen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.metabolism.urineen
dc.subject.otherAnimalsen
dc.subject.otherBicyclo Compounds.metabolismen
dc.subject.otherBiotransformationen
dc.subject.otherFemaleen
dc.subject.otherGas Chromatography-Mass Spectrometryen
dc.subject.otherGlucuronates.metabolismen
dc.subject.otherHydrolysisen
dc.subject.otherIndoles.metabolismen
dc.subject.otherMaleen
dc.subject.otherPerindoprilen
dc.subject.otherRamiprilen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.titleBiotransformation studies of di-acid angiotensin converting enzyme inhibitors.en
dc.typeJournal Articleen
dc.identifier.journaltitleArzneimittel-Forschungen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria (Australia).en
dc.description.pages1225-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2964241en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
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