Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12856
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dc.contributor.authorSakaguchi, Ken
dc.contributor.authorChai, Syn Yen
dc.contributor.authorJackson, Ben
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T02:36:15Z
dc.date.available2015-05-16T02:36:15Z
dc.date.issued1988-03-01en
dc.identifier.citationHypertension; 11(3): 230-8en
dc.identifier.govdoc2832327en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12856en
dc.description.abstractInhibition of angiotensin converting enzyme (ACE) in serum and tissues of rats was studied after administration of lisinopril, an ACE inhibitor. Tissue ACE was assessed by quantitative in vitro autoradiography using the ACE inhibitor [125I]351A, as a ligand, and serum ACE was measured by a fluorimetric method. Following oral administration of lisinopril (10 mg/kg), serum ACE activity was acutely reduced but recovered gradually over 24 hours. Four hours after lisinopril administration, ACE activity was markedly inhibited in kidney (11% of control level), adrenal (8%), duodenum (8%), and lung (33%; p less than 0.05). In contrast, ACE in testis was little altered by lisinopril (96%). In brain, ACE activity was markedly reduced 4 hours after lisinopril administration in the circumventricular organs, including the subfornical organ (16-22%) and organum vasculosum of the lamina terminalis (7%; p less than 0.05). In other areas of the brain, including the choroid plexus and caudate putamen, ACE activity was unchanged. Twenty-four hours after administration, ACE activity in peripheral tissues and the circumventricular organs of the brain had only partially recovered toward control levels, as it was still below 50% of control activity levels. These results establish that lisinopril has differential effects on inhibiting ACE in different tissues and suggest that the prolonged tissue ACE inhibition after a single oral dose of lisinopril may reflect targets involved in the hypotensive action of ACE inhibitors.en
dc.language.isoenen
dc.subject.otherAdrenal Glands.enzymologyen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherBrain.enzymologyen
dc.subject.otherDipeptides.diagnostic useen
dc.subject.otherDuodenum.enzymologyen
dc.subject.otherEnalapril.analogs & derivatives.pharmacologyen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherKidney.enzymologyen
dc.subject.otherLisinoprilen
dc.subject.otherLung.enzymologyen
dc.subject.otherMaleen
dc.subject.otherPeptidyl-Dipeptidase A.analysisen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherRenin-Angiotensin System.drug effectsen
dc.subject.otherTestis.enzymologyen
dc.subject.otherTime Factorsen
dc.titleInhibition of tissue angiotensin converting enzyme. Quantitation by autoradiography.en
dc.typeJournal Articleen
dc.identifier.journaltitleHypertensionen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages230-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2832327en
dc.type.austinJournal Articleen
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptGastroenterology and Hepatology-
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