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https://ahro.austin.org.au/austinjspui/handle/1/12771| Title: | Serotonin in panic disorder: platelet uptake and concentration. | Austin Authors: | McIntyre, I M;Judd, F K;Burrows, Graham D;Norman, Trevor R | Affiliation: | Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Jan-1989 | Publication information: | International Clinical Psychopharmacology; 4(1): 1-6 | Abstract: | Platelet serotonin uptake and platelet serotonin concentrations were measured in 17 patients (5 males, 12 females) with panic attacks and 15 controls (8 males, 7 females). Higher Vmax values were found in the patient group compared with controls (65 +/- 7 vs. 47 +/- 3 pmol/10(8) platelets/min; p less than 0.05) while the affinity constant Km was not significantly different (0.6 +/- 0.1 vs. 0.5 +/- 0.1 microM). Platelet serotonin concentrations were not significantly different between the two groups (38 +/- 4 vs. 41 +/- 4 ng/10(8) platelets). These results confirm our earlier finding of increased serotonin uptake in patients with panic attacks and suggest that platelet serotonin levels are normal. | Gov't Doc #: | 2592755 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12771 | Journal: | International clinical psychopharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/2592755 | Type: | Journal Article | Subjects: | Adult Blood Platelets.metabolism Fear Female Humans Kinetics Male Panic.physiology Serotonin.blood |
| Appears in Collections: | Journal articles |
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