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dc.contributor.authorErnst, Matthiasen
dc.contributor.authorPreaudet, Adeleen
dc.contributor.authorPutoczki, Tracyen
dc.identifier.citationJournal of Visualized Experiments; 2015; (97): e52383en
dc.description.abstractAnimal models of inflammatory bowel disease (IBD) and colorectal cancer (CRC) have provided significant insight into the cell intrinsic and extrinsic mechanisms that contribute to the onset and progression of intestinal diseases. The identification of new molecules that promote these pathologies has led to a flurry of activity focused on the development of potential new therapies to inhibit their function. As a result, various pre-clinical mouse models with an intact immune system and stromal microenvironment are now heavily used. Here we describe three experimental protocols to test the efficacy of new therapeutics in pre-clinical models of (1) acute mucosal damage, (2) chronic colitis and/or colitis-associated colon cancer, and (3) sporadic colorectal cancer. We also outline procedures for serial endoscopic examination that can be used to document the therapeutic response of an individual tumor and to monitor the health of individual mice. These protocols provide complementary experimental platforms to test the effectiveness of therapeutic compounds shown to be well tolerated by mice.en
dc.titleNon-invasive assessment of the efficacy of new therapeutics for intestinal pathologies using serial endoscopic imaging of live miceen
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Visualized Experimentsen
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia-
dc.identifier.affiliationThe Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australiaen
dc.identifier.affiliationThe Department of Medical Biology, University of Melbourne, Victoria, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextWith Fulltext-
item.openairecristype Newton-John Cancer Research Institute-
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