Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12709
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dc.contributor.authorLandoni, Giovannien
dc.contributor.authorComis, Marcoen
dc.contributor.authorConte, Massimilianoen
dc.contributor.authorFinco, Gabrieleen
dc.contributor.authorMucchetti, Martaen
dc.contributor.authorPaternoster, Gianlucaen
dc.contributor.authorPisano, Antonioen
dc.contributor.authorRuggeri, Lauraen
dc.contributor.authorAlvaro, Gabrieleen
dc.contributor.authorAngelone, Manuelaen
dc.contributor.authorBergonzi, Pier Cen
dc.contributor.authorBocchino, Speranzaen
dc.contributor.authorBorghi, Giovannien
dc.contributor.authorBove, Tizianaen
dc.contributor.authorBuscaglia, Giuseppeen
dc.contributor.authorCabrini, Lucaen
dc.contributor.authorCallegher, Linoen
dc.contributor.authorCaramelli, Fabioen
dc.contributor.authorColombo, Sergioen
dc.contributor.authorCorno, Lauraen
dc.contributor.authorDel Sarto, Paoloen
dc.contributor.authorFeltracco, Paoloen
dc.contributor.authorForti, Alessandroen
dc.contributor.authorGanzaroli, Marcoen
dc.contributor.authorGreco, Massimilianoen
dc.contributor.authorGuarracino, Fabioen
dc.contributor.authorLembo, Rosalbaen
dc.contributor.authorLobreglio, Rosettaen
dc.contributor.authorMeroni, Robertaen
dc.contributor.authorMonaco, Fabrizioen
dc.contributor.authorMusu, Marioen
dc.contributor.authorPala, Giovannien
dc.contributor.authorPasin, Lauraen
dc.contributor.authorPieri, Marinaen
dc.contributor.authorPisarra, Stefaniaen
dc.contributor.authorPonticelli, Giuseppeen
dc.contributor.authorRoasio, Agostinoen
dc.contributor.authorSantini, Francescoen
dc.contributor.authorSilvetti, Simonaen
dc.contributor.authorSzékely, Andreaen
dc.contributor.authorZambon, Massimoen
dc.contributor.authorZucchetti, Maria Chiaraen
dc.contributor.authorZangrillo, Albertoen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T02:26:23Z-
dc.date.available2015-05-16T02:26:23Z-
dc.date.issued2015-03-27en
dc.identifier.citationCritical Care Medicine, 2015-03-27en
dc.identifier.govdoc25821918en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12709en
dc.description.abstractWe aimed to identify all treatments that affect mortality in adult critically ill patients in multicenter randomized controlled trials. We also evaluated the methodological aspects of these studies, and we surveyed clinicians' opinion and usual practice for the selected interventions.MEDLINE/PubMed, Scopus, and Embase were searched. Further articles were suggested for inclusion from experts and cross-check of references.We selected the articles that fulfilled the following criteria: publication in a peer-reviewed journal; multicenter randomized controlled trial design; dealing with nonsurgical interventions in adult critically ill patients; and statistically significant effect in unadjusted landmark mortality. A consensus conference assessed all interventions and excluded those with lack of reproducibility, lack of generalizability, high probability of type I error, major baseline imbalances between intervention and control groups, major design flaws, contradiction by subsequent larger higher quality trials, modified intention to treat analysis, effect found only after adjustments, and lack of biological plausibility.For all selected studies, we recorded the intervention and its comparator, the setting, the sample size, whether enrollment was completed or interrupted, the presence of blinding, the effect size, and the duration of follow-up.We found 15 interventions that affected mortality in 24 multicenter randomized controlled trials. Median sample size was small (199 patients) as was median centers number (10). Blinded trials enrolled significantly more patients and involved more centers. Multicenter randomized controlled trials showing harm also involved significantly more centers and more patients (p = 0.016 and p = 0.04, respectively). Five hundred fifty-five clinicians from 61 countries showed variable agreement on perceived validity of such interventions.We identified 15 treatments that decreased/increased mortality in critically ill patients in 24 multicenter randomized controlled trials. However, design affected trial size and larger trials were more likely to show harm. Finally, clinicians view of such trials and their translation into practice varied.en
dc.language.isoenen
dc.titleMortality in Multicenter Critical Care Trials: An Analysis of Interventions With a Significant Effect.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Care Medicineen
dc.identifier.affiliationFTGM-"G. Pasquinucci" Heart Hospital, Massa, Italyen
dc.identifier.affiliationAnesthesia and Resuscitation, United Company Hospital Papardo-Piemonte, Messina, Italyen
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, University of Cagliari, Cagliari, Italyen
dc.identifier.affiliationCardioanesthesia and Intensive Care, Civil Hospital "SS Annunziata," Sassari, Italyen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationCardiovascular Anesthesia and Intensive Care, San Carlo Hospital, Potenza, Italyen
dc.identifier.affiliationDivision of Cardiac Anesthesia and Intensive Care, Azienda Ospedaliera Dei Colli, V Monaldi, Naples, Italyen
dc.identifier.affiliationA.O. Mater Domini Germaneto, Catanzaro, Italy.en
dc.identifier.affiliationCardioanesthesia and Intensive Care, IRCCS University Hospital San Martino Ist, Genova, Italy.en
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, S. Maria dei Battuti Hospital ULSS 9, Treviso, Italyen
dc.identifier.affiliationCardiothoracic and Vascular Anesthesia and Intensive Care, S. Orsola-Malpighi University Hospital, Bologna, Italyen
dc.identifier.affiliationCardiac and Vascular Department, Casa di Cura Villa Verde, Taranto, Italyen
dc.identifier.affiliationDivision of Cardiac Surgery, University of Genova Medical School, Genova, Italyen
dc.identifier.affiliationDepartment of Anesthesiology and Intensive Care, Semmelweis University, Budapest, Hungaryen
dc.identifier.affiliationDepartment of Anesthesia, Intensive Care Medicine, Cardinal Massaia Hospital, Asti, Italyen
dc.identifier.affiliationDepartment of Anaesthesia and Critical care medicine, University Hospital of Pisa, Pisa, Italyen
dc.identifier.affiliationAnesthesia and Critical care medicine, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italyen
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.en
dc.identifier.affiliationCardiac and Vascular Department, Mauriziano Hospital, Turin, Italy.en
dc.identifier.affiliationDepartment of Medical Sciences "M. Aresu," University of Cagliari, Cagliari, Italyen
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, Maria Cecilia Hospital - GVM Care & Research, Cotignola (RA), Italyen
dc.identifier.affiliationDepartment of Pharmacology and Anesthesiology, University Hospital of Padova, Padova, Italyen
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, "S. Maria di Ca' Foncello," Treviso, Italyen
dc.identifier.doi10.1097/CCM.0000000000000974en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25821918en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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