Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12674
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dc.contributor.authorGranger, Catherine Len
dc.contributor.authorHolland, Anne Een
dc.contributor.authorGordon, Ian Ren
dc.contributor.authorDenehy, Lindaen
dc.date.accessioned2015-05-16T02:24:07Z
dc.date.available2015-05-16T02:24:07Z
dc.date.issued2015-03-06en
dc.identifier.citationChronic Respiratory Disease 2015; 12(2): 146-54en
dc.identifier.govdoc25749346en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12674en
dc.description.abstractThe 6-minute walk distance (6MWD) is one of the most commonly used measures of functional capacity in lung cancer, however, the minimal important difference (MID) has not been established. The aims of this exploratory study are, in lung cancer, to estimate (1) the MID of the 6MWD and (2) relationship between 6MWD, demographic and disease-related factors. Fifty-six participants with stage I-IV lung cancer completed the 6MWD prior to treatment and 10 weeks later. No exercise intervention occurred. Additional measures included European Organization for Research and Treatment of Cancer questionnaire (EORTC-QLQ-C30) and questionnaires assessing function, physical activity and symptoms. MID was calculated using anchor- and distribution-based methods. The mean 6MWD decline in participants classed as deteriorated was 60 m compared with 16 m in participants classed as not-deteriorated (p = 0.01). The receiver operating curve indicated a cut-off value for clinically relevant change to be 42 m (95% confidence interval (CI) 6-75) (area under curve = 0.66, 95% CI 0.51-0.81) or a 9.5% change. Distribution-based methods indicated an MID between 22 m (95% CI 18-26) and 32 m (95% CI 20-42). Higher 6MWD correlated with better function (r = -0.42, p = 0.001), physical activity (r = 0.56, p < 0.005) and dyspnoea (r = -0.44, p = 0.001). The MID for deterioration of the 6MWD in lung cancer is estimated to be between 22 m and 42 m or a change of 9.5%.en
dc.language.isoenen
dc.subject.other6-minute walk distance (6MWD)en
dc.subject.otherLung canceren
dc.subject.otherMIDen
dc.subject.otherfunctional capacityen
dc.subject.otherminimal important differenceen
dc.titleMinimal important difference of the 6-minute walk distance in lung cancer.en
dc.typeJournal Articleen
dc.identifier.journaltitleChronic respiratory diseaseen
dc.identifier.affiliationStatistical Consulting Centre, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Physiotherapy, The University of Melbourne, Parkville, Victoria, Australia Institute for Breathing and Sleep, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationInstitute for Breathing and Sleep, Austin Hospital, Heidelberg, Victoria, Australia Department of Physiotherapy, La Trobe University, Melbourne, Victoria, Australia Department of Physiotherapy, Alfred Hospital, Prahran, Victoria, Australiaen
dc.identifier.affiliationDepartment of Physiotherapy, The University of Melbourne, Parkville, Victoria, Australia Department of Physiotherapy, Royal Melbourne Hospital, Parkville, Victoria, Australia Institute for Breathing and Sleep, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1177/1479972315575715en
dc.description.pages146-54en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25749346en
dc.type.austinJournal Articleen
local.name.researcherGranger, Catherine L
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptPhysiotherapy-
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