Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12650
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dc.contributor.authorZantomio, Danielaen
dc.contributor.authorChana, Gursharanen
dc.contributor.authorLaskaris, Lilianaen
dc.contributor.authorTesta, Reneeen
dc.contributor.authorEverall, Ianen
dc.contributor.authorPantelis, Christosen
dc.contributor.authorSkafidas, Efstratiosen
dc.date.accessioned2015-05-16T02:22:36Z
dc.date.available2015-05-16T02:22:36Z
dc.date.issued2015-02-19en
dc.identifier.citationNeuroscience and Biobehavioral Reviews 2015; 52(): 172-7en
dc.identifier.govdoc25704074en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12650en
dc.description.abstractThe pathogenesis of Autism Spectrum Disorder (ASD), a serious neurodevelopmental disorder, is poorly understood. We review evidence for alterations in glutamatergic signalling in the aetiology of ASD, with a focus on the metabotropic glutamate receptor-5 (mGluR5). mGluR5 signalling is important for synapse formation, neuroplasticity and long term potentiation as well as neuroprotection and has been shown to have a regulatory role in neuroinflammation. Evidence for neuroinflammation in ASD is supported by increase in pro-inflammatory cytokines in the blood and cerebrospinal fluid (CSF) and increased number and activation of microglia in postmortem dorsolateral prefrontal cortex (DLPFC). mGlur5 signalling has also been shown to downregulate microglial activation. Therefore, we focus on mGluR5 as a potential unifying explanation for synapse alteration and neuroinflammation seen in ASD. Data from mGluR5 knockout mouse models, and syndromic and non syndromic forms of ASD are discussed in relation to how alterations in mGluR5 are associated with ASD symptoms. This review supports altered mGluR5 functioning as a convergent point in ASD pathogenesis and indicates more research is warranted into mGluR5 as a potential therapeutic target.en
dc.language.isoenen
dc.subject.otherAutism spectrum disorderen
dc.subject.otherGRM5en
dc.subject.otherGlutamateen
dc.subject.otherMicrogliaen
dc.subject.otherNeurodevelopmenten
dc.subject.otherNeuroinflammationen
dc.subject.othermGluR5en
dc.titleConvergent evidence for mGluR5 in synaptic and neuroinflammatory pathways implicated in ASD.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroscience and biobehavioral reviewsen
dc.identifier.affiliationMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Haematology, Austin Health, Heidelberg, VIC, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Australiaen
dc.identifier.affiliationCentre for Neural Engineering, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Psychiatry, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationDepartment of Psychology, Monash University, Clayton, Vic, Australiaen
dc.identifier.affiliationCentre for Integrative Brain Function, Australiaen
dc.identifier.doi10.1016/j.neubiorev.2015.02.006en
dc.description.pages172-177en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25704074en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Haematology-
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