Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12596
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dc.contributor.authorBolton, Damien Men
dc.contributor.authorOng, Kevinen
dc.contributor.authorGiles, Graham Gen
dc.contributor.authorSeveri, Gianlucaen
dc.contributor.authorLawrentschuk, Nathanen
dc.contributor.authorPapa, Nathan Pen
dc.contributor.authorTroy, Andrew Jen
dc.contributor.authorWoo, Henryen
dc.contributor.authorMillar, Jeremy Len
dc.contributor.authorRoyce, Peteren
dc.date.accessioned2015-05-16T02:18:45Z
dc.date.available2015-05-16T02:18:45Z
dc.date.issued2015-03-16en
dc.identifier.citationJournal of Endourology / Endourological Society 2015; 29(7): 844-9en
dc.identifier.govdoc25621993en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12596en
dc.description.abstractTo determine the oncologic and complication outcomes of treatment of patients with localized prostate cancer by high intensity focused ultrasound (HIFU) for primary management of prostate cancer in a whole of population, multiuser series.We created a centralized database-accessible only by nonurologist researchers-within a cancer epidemiology center, after ethics approval from that institution. A single researcher prospectively entered baseline, treatment, and clinical/biochemical follow-up data from all patients treated with HIFU in the state of Victoria over the study period.We accrued 108 patients, of whom 103 had been staged as having clinically localized disease. Ninety-three patients (86.1%) had low- or intermediate-risk prostate cancer. Forty-four patients (40.5%) had persistent mild urinary incontinence at 3 months after treatment, and 3 of these ultimately underwent further surgical procedures to correct incontinence. Twenty-seven patients (25%) additionally experienced occasions of urinary retention in the first 3 months after treatment because of passage of tissue. Twenty-nine patients had achieved a prostate-specific antigen level of <0.2 ng/mL at 3 months after HIFU. Fifty-six patients underwent post-HIFU prostate biopsy, and this was positive for residual cancer in 51 cases. Forty-five of the patients who had a positive post-HIFU biopsy underwent secondary treatment for prostate cancer.Oncologic control and complication outcomes in this cohort were inferior to those previously reported for HIFU in single-user series. Given the population-based multiuser nature of our series, we believe our observations are more likely to reflect the community outcomes that might be expected from widespread adoption of HIFU than generalizing from single-operator series.en
dc.language.isoenen
dc.titleA Whole of Population, Multiuser Series of High-Intensity Focused Ultrasound for Management of Localized Prostate Cancer: Outcomes and Implications.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of endourology / Endourological Societyen
dc.identifier.affiliationDepartment of Urology, Austin Health, and Department of Surgery, University of Melbourne , Melbourne, Victoria, Australia .en
dc.identifier.doi10.1089/end.2014.0696en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25621993en
dc.type.austinJournal Articleen
local.name.researcherBolton, Damien M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
crisitem.author.deptUrology-
crisitem.author.deptUrology-
crisitem.author.deptSurgery-
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