Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12583
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dc.contributor.authorAl-Fiadh, Ali Hen
dc.contributor.authorWong, Tien Yen
dc.contributor.authorKawasaki, Ryoen
dc.contributor.authorClark, David Jen
dc.contributor.authorPatel, Sheila Ken
dc.contributor.authorFreeman, Melanieen
dc.contributor.authorWilson, Andrewen
dc.contributor.authorBurrell, Louise Men
dc.contributor.authorFarouque, Omaren
dc.date.accessioned2015-05-16T02:17:58Z
dc.date.available2015-05-16T02:17:58Z
dc.date.issued2014-12-18en
dc.identifier.citationThe American Journal of Cardiology 2014; 115(5): 609-13en
dc.identifier.govdoc25591896en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12583en
dc.description.abstractEndothelial dysfunction is a key feature of atherosclerosis. Retinal microvascular endothelial function can be assessed using noninvasive dynamic vessel imaging techniques. Whether it is impaired in subjects with coronary artery disease (CAD) is unknown. The aim of this study was to examine the relation of retinal microvascular endothelial function with CAD. Vascular studies were performed in 197 prospectively recruited subjects divided into 2 groups: those without CAD but ≥2 cardiovascular risk factors (non-CAD controls; n = 119) and those with stable CAD (n = 78). Retinal microvascular endothelial dysfunction was assessed by measuring retinal arteriolar and venular dilatation to flicker light, a nitric oxide-dependent phenomenon, expressed as percentage increase over baseline diameter. Fingertip pulse-volume amplitude was measured to calculate reactive hyperaemia index and brachial artery flow-mediated dilatation assessed as measures of peripheral microvascular and conduit vessel endothelial function, respectively. Mean retinal arteriolar dilatation was attenuated in patients with CAD compared with non-CAD controls (1.51 ± 1.51% vs 2.37 ± 1.95%, p = 0.001). Retinal arteriolar dilatation was independently associated with CAD after adjustment for age, gender, cardiovascular risk factors, and medication use (odds ratio 1.60, 95% confidence interval 1.14 to 2.25, p = 0.007). Reactive hyperaemia index and flow-mediated dilatation were not different. In conclusion, the capacity of retinal arterioles to dilate in response to flicker light is an independent predictor of the presence of CAD and suggests that retinal microvascular endothelial dysfunction is a marker for underlying CAD.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherArterioles.physiopathologyen
dc.subject.otherCase-Control Studiesen
dc.subject.otherCoronary Artery Disease.physiopathologyen
dc.subject.otherEndothelium, Vascular.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMicrocirculation.physiologyen
dc.subject.otherMiddle Ageden
dc.subject.otherRetinal Vessels.physiopathologyen
dc.subject.otherRisk Factorsen
dc.subject.otherVasoconstriction.physiologyen
dc.subject.otherVasodilation.physiologyen
dc.subject.otherVenules.physiopathologyen
dc.titleUsefulness of retinal microvascular endothelial dysfunction as a predictor of coronary artery disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe American journal of cardiologyen
dc.identifier.affiliationCentre for Eye Research Australia, East Melbourne, Australiaen
dc.identifier.affiliationDepartment of Cardiology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Public Health, Yamagata University, Yamagata, Japan.en
dc.identifier.affiliationSingapore Eye Research Institute, National University of Singapore, Singapore.en
dc.identifier.doi10.1016/j.amjcard.2014.12.011en
dc.description.pages609-13en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25591896en
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptCardiology-
crisitem.author.deptUniversity of Melbourne Clinical School-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
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